Detailed information of TA system TA199137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1599209..1599801
• Replicon: chromosome
• Accession: NZ_CP072901
• Organism: Bartonella henselae strain Berlin-I

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A829Z6B5
• Locus tag: KAE72_RS06890
• Protein ID: WP_034447446.1
• Coordinates: 1599601..1599801 (-)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A840E534
• Locus tag: KAE72_RS06885
• Protein ID: WP_011180290.1
• Coordinates: 1599209..1599604 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE72_RS06855 (KAE72_06720)	1594474..1595232	-	759	WP_011180282.1	phage antirepressor Ant	-
KAE72_RS06860 (KAE72_06725)	1595292..1595807	-	516	WP_011180283.1	phage antirepressor Ant	-
KAE72_RS06865 (KAE72_06730)	1595824..1596663	-	840	WP_011180284.1	antA/AntB antirepressor family protein	-
KAE72_RS06870 (KAE72_06735)	1596695..1597237	-	543	WP_011180285.1	phage antirepressor Ant	-
KAE72_RS06875 (KAE72_06740)	1597834..1598412	-	579	WP_011180287.1	hypothetical protein	-
KAE72_RS06880 (KAE72_06745)	1598416..1598736	-	321	WP_011180288.1	hypothetical protein	-
KAE72_RS06885 (KAE72_06750)	1599209..1599604	-	396	WP_011180290.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KAE72_RS06890 (KAE72_06755)	1599601..1599801	-	201	WP_034447446.1	type II toxin-antitoxin system HicA family toxin	Toxin
KAE72_RS06895 (KAE72_06760)	1599866..1600402	-	537	WP_034447444.1	hypothetical protein	-
KAE72_RS06900 (KAE72_06765)	1600413..1600859	-	447	WP_011180293.1	single-stranded DNA-binding protein	-
KAE72_RS06905 (KAE72_06770)	1601050..1601331	+	282	WP_011180826.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KAE72_RS06910 (KAE72_06775)	1601348..1601641	+	294	WP_034447441.1	HigA family addiction module antitoxin	-
KAE72_RS06915 (KAE72_06780)	1601683..1602009	-	327	WP_034447437.1	hypothetical protein	-
KAE72_RS06920 (KAE72_06785)	1602174..1602593	-	420	WP_038525124.1	hypothetical protein	-
KAE72_RS06925 (KAE72_06790)	1602586..1603698	-	1113	WP_011180297.1	DUF1376 domain-containing protein	-
KAE72_RS06930 (KAE72_06795)	1603688..1604035	-	348	WP_011180298.1	DUF1376 domain-containing protein	-
KAE72_RS06935 (KAE72_06800)	1604028..1604504	-	477	WP_011180299.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1551314..1618522	67208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-125)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7492.81 Da
• Isoelectric Point: 10.9914

>T199137 WP_034447446.1 NZ_CP072901:c1599801-1599601 [Bartonella henselae]
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE

Nucleotide

• Length: 201 bp

>T199137 NZ_CP097213:2688320-2688427 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14718.71 Da
• Isoelectric Point: 4.3191

>AT199137 WP_011180290.1 NZ_CP072901:c1599604-1599209 [Bartonella henselae]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI

Nucleotide

• Length: 396 bp

>AT199137 NZ_CP097213:c2688273-2688207 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A829Z6B5

Antitoxin

• AlphaFold DB: A0A840E534