Detailed information of TA system TA199136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1593625..1594156
• Replicon: chromosome
• Accession: NZ_CP072901
• Organism: Bartonella henselae strain Berlin-I

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X5M5T9
• Locus tag: KAE72_RS06845
• Protein ID: WP_011180281.1
• Coordinates: 1593875..1594156 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A0H3LWD6
• Locus tag: KAE72_RS06840
• Protein ID: WP_011180280.1
• Coordinates: 1593625..1593888 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE72_RS06815 (KAE72_06680)	1589771..1590019	-	249	WP_011180274.1	hypothetical protein	-
KAE72_RS06820 (KAE72_06685)	1590023..1591951	-	1929	WP_011180275.1	phage terminase large subunit family protein	-
KAE72_RS06825 (KAE72_06690)	1591944..1592525	-	582	WP_011180276.1	hypothetical protein	-
KAE72_RS06830 (KAE72_06695)	1592588..1592902	+	315	WP_011180277.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KAE72_RS06835 (KAE72_06700)	1592919..1593215	+	297	WP_011180278.1	HigA family addiction module antitoxin	-
KAE72_RS06840 (KAE72_06705)	1593625..1593888	+	264	WP_011180280.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KAE72_RS06845 (KAE72_06710)	1593875..1594156	+	282	WP_011180281.1	type II toxin-antitoxin system YafQ family toxin	Toxin
KAE72_RS06850 (KAE72_06715)	1594199..1594477	-	279	WP_011180242.1	hypothetical protein	-
KAE72_RS06855 (KAE72_06720)	1594474..1595232	-	759	WP_011180282.1	phage antirepressor Ant	-
KAE72_RS06860 (KAE72_06725)	1595292..1595807	-	516	WP_011180283.1	phage antirepressor Ant	-
KAE72_RS06865 (KAE72_06730)	1595824..1596663	-	840	WP_011180284.1	antA/AntB antirepressor family protein	-
KAE72_RS06870 (KAE72_06735)	1596695..1597237	-	543	WP_011180285.1	phage antirepressor Ant	-
KAE72_RS06875 (KAE72_06740)	1597834..1598412	-	579	WP_011180287.1	hypothetical protein	-
KAE72_RS06880 (KAE72_06745)	1598416..1598736	-	321	WP_011180288.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1551314..1618522	67208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-82)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11106.85 Da
• Isoelectric Point: 10.3380

>T199136 WP_011180281.1 NZ_CP072901:1593875-1594156 [Bartonella henselae]
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL

Nucleotide

• Length: 282 bp

>T199136 NZ_CP097213:c2474020-2473844 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9565.81 Da
• Isoelectric Point: 4.1403

>AT199136 WP_011180280.1 NZ_CP072901:1593625-1593888 [Bartonella henselae]
MATSRMVQARVPEEIQNVASQVIQASGLTVSDVVRVLMTRIAQDKAIPSVLFQPNAETIAAFAEVDEGNLKKFHSVDELF
DDLYADD

Nucleotide

• Length: 264 bp

>AT199136 NZ_CP097213:c2473798-2473382 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0R4J6H3

Antitoxin

• AlphaFold DB: A0A0H3LWD6