Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 296269..296748 Replicon chromosome
Accession NZ_CP072901
Organism Bartonella henselae strain Berlin-I

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KAE72_RS01440 Protein ID WP_236087019.1
Coordinates 296269..296421 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A829YZI5
Locus tag KAE72_RS01445 Protein ID WP_034447857.1
Coordinates 296521..296748 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE72_RS01420 (KAE72_01410) 293548..294687 - 1140 WP_049784545.1 phage terminase large subunit -
KAE72_RS01425 (KAE72_01415) 294668..294994 - 327 WP_011180626.1 hypothetical protein -
KAE72_RS01430 (KAE72_01420) 295293..295751 + 459 WP_011180624.1 hypothetical protein -
KAE72_RS01435 (KAE72_01425) 295850..296239 + 390 WP_011180623.1 hypothetical protein -
KAE72_RS01440 296269..296421 - 153 WP_236087019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KAE72_RS01445 (KAE72_01435) 296521..296748 - 228 WP_034447857.1 DUF6290 family protein Antitoxin
KAE72_RS01450 (KAE72_01440) 296845..297339 - 495 WP_011180825.1 hypothetical protein -
KAE72_RS01455 (KAE72_01445) 297393..297839 - 447 WP_011180617.1 single-stranded DNA-binding protein -
KAE72_RS01460 (KAE72_01450) 298030..298311 + 282 WP_011180826.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAE72_RS01465 (KAE72_01455) 298328..298621 + 294 WP_034447441.1 HigA family addiction module antitoxin -
KAE72_RS01470 (KAE72_01460) 298663..298989 - 327 WP_011180827.1 hypothetical protein -
KAE72_RS01480 (KAE72_01470) 299564..299869 - 306 WP_011180828.1 ETC complex I subunit -
KAE72_RS01490 (KAE72_01480) 300863..301552 - 690 WP_011180829.1 DnaA regulatory inactivator HdaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-48)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5819.95 Da        Isoelectric Point: 10.3747

>T199134 WP_236087019.1 NZ_CP072901:c296421-296269 [Bartonella henselae]
VRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAVGHRKNIYKG

Download         Length: 153 bp

>T199134 NZ_CP097213:2076088-2076191 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8714.77 Da        Isoelectric Point: 4.8780

>AT199134 WP_034447857.1 NZ_CP072901:c296748-296521 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRKGEGTFYSSEEVRKELGLDD

Download         Length: 228 bp

>AT199134 NZ_CP097213:c2076229-2075958 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829YZI5

References