Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 261832..262312 | Replicon | chromosome |
| Accession | NZ_CP072901 | ||
| Organism | Bartonella henselae strain Berlin-I | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | A0A067WDE7 |
| Locus tag | KAE72_RS01220 | Protein ID | WP_011180622.1 |
| Coordinates | 261832..262101 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | N6VJG4 |
| Locus tag | KAE72_RS01225 | Protein ID | WP_007346764.1 |
| Coordinates | 262085..262312 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE72_RS01195 (KAE72_01180) | 256886..258940 | - | 2055 | WP_011180822.1 | portal protein | - |
| KAE72_RS01200 (KAE72_01185) | 258925..260250 | - | 1326 | WP_011180823.1 | phage terminase large subunit | - |
| KAE72_RS01205 (KAE72_01190) | 260231..260557 | - | 327 | WP_011180626.1 | hypothetical protein | - |
| KAE72_RS01210 (KAE72_01195) | 260856..261314 | + | 459 | WP_011180624.1 | hypothetical protein | - |
| KAE72_RS01215 | 261410..261802 | + | 393 | WP_075320637.1 | hypothetical protein | - |
| KAE72_RS01220 (KAE72_01200) | 261832..262101 | - | 270 | WP_011180622.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KAE72_RS01225 (KAE72_01205) | 262085..262312 | - | 228 | WP_007346764.1 | DUF6290 family protein | Antitoxin |
| KAE72_RS01230 (KAE72_01210) | 262420..262752 | - | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| KAE72_RS01235 (KAE72_01215) | 262752..263009 | - | 258 | WP_034448603.1 | antitoxin | - |
| KAE72_RS01240 (KAE72_01220) | 263090..263584 | - | 495 | WP_059443338.1 | hypothetical protein | - |
| KAE72_RS01245 (KAE72_01225) | 263638..264084 | - | 447 | WP_011180617.1 | single-stranded DNA-binding protein | - |
| KAE72_RS01250 (KAE72_01230) | 264296..264586 | + | 291 | WP_011180616.1 | hypothetical protein | - |
| KAE72_RS01255 (KAE72_01235) | 264583..264855 | + | 273 | WP_011180615.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| KAE72_RS01260 (KAE72_01240) | 265046..265363 | - | 318 | Protein_242 | hypothetical protein | - |
| KAE72_RS01265 (KAE72_01245) | 265545..265931 | - | 387 | WP_082246570.1 | hypothetical protein | - |
| KAE72_RS01270 (KAE72_01250) | 265915..267165 | - | 1251 | WP_011180612.1 | DUF1376 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 235927..276049 | 40122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10495.44 Da Isoelectric Point: 10.2009
>T199130 WP_011180622.1 NZ_CP072901:c262101-261832 [Bartonella henselae]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAV
GHRKNIYKG
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAV
GHRKNIYKG
Download Length: 270 bp
>T199130 NZ_CP097213:1091500-1091835 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 76 a.a. Molecular weight: 8742.78 Da Isoelectric Point: 4.8780
>AT199130 WP_007346764.1 NZ_CP072901:c262312-262085 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
Download Length: 228 bp
>AT199130 NZ_CP097213:1091252-1091500 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067WDE7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | N6VJG4 |