Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-dinJ/YafQ-RelB |
| Location | 715095..715626 | Replicon | chromosome |
| Accession | NZ_CP072900 | ||
| Organism | Bartonella henselae strain G-5436 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | X5M5T9 |
| Locus tag | KAE71_RS03265 | Protein ID | WP_011180281.1 |
| Coordinates | 715095..715376 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | A0A0H3LWD6 |
| Locus tag | KAE71_RS03270 | Protein ID | WP_011180280.1 |
| Coordinates | 715363..715626 (-) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE71_RS03230 (KAE71_03215) | 710515..710835 | + | 321 | WP_011180288.1 | hypothetical protein | - |
| KAE71_RS03235 (KAE71_03220) | 710839..711417 | + | 579 | WP_011180287.1 | hypothetical protein | - |
| KAE71_RS03240 (KAE71_03225) | 712014..712556 | + | 543 | WP_011180285.1 | phage antirepressor Ant | - |
| KAE71_RS03245 (KAE71_03230) | 712588..713427 | + | 840 | WP_011180284.1 | antA/AntB antirepressor family protein | - |
| KAE71_RS03250 (KAE71_03235) | 713444..713959 | + | 516 | WP_011180283.1 | phage antirepressor Ant | - |
| KAE71_RS03255 (KAE71_03240) | 714019..714777 | + | 759 | WP_011180282.1 | phage antirepressor Ant | - |
| KAE71_RS03260 (KAE71_03245) | 714774..715052 | + | 279 | WP_011180242.1 | hypothetical protein | - |
| KAE71_RS03265 (KAE71_03250) | 715095..715376 | - | 282 | WP_011180281.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| KAE71_RS03270 (KAE71_03255) | 715363..715626 | - | 264 | WP_011180280.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| KAE71_RS03275 (KAE71_03260) | 716036..716332 | - | 297 | WP_011180278.1 | HigA family addiction module antitoxin | - |
| KAE71_RS03280 (KAE71_03265) | 716349..716663 | - | 315 | WP_011180277.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE71_RS03285 (KAE71_03270) | 716726..717307 | + | 582 | WP_011180276.1 | hypothetical protein | - |
| KAE71_RS03290 (KAE71_03275) | 717300..719228 | + | 1929 | WP_011180275.1 | phage terminase large subunit family protein | - |
| KAE71_RS03295 (KAE71_03280) | 719232..719480 | + | 249 | WP_011180274.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 690729..757937 | 67208 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11106.85 Da Isoelectric Point: 10.3380
>T199128 WP_011180281.1 NZ_CP072900:c715376-715095 [Bartonella henselae]
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL
Download Length: 282 bp
>T199128 NZ_CP097213:c791229-790852 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAATGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAATGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9565.81 Da Isoelectric Point: 4.1403
>AT199128 WP_011180280.1 NZ_CP072900:c715626-715363 [Bartonella henselae]
MATSRMVQARVPEEIQNVASQVIQASGLTVSDVVRVLMTRIAQDKAIPSVLFQPNAETIAAFAEVDEGNLKKFHSVDELF
DDLYADD
MATSRMVQARVPEEIQNVASQVIQASGLTVSDVVRVLMTRIAQDKAIPSVLFQPNAETIAAFAEVDEGNLKKFHSVDELF
DDLYADD
Download Length: 264 bp
>AT199128 NZ_CP097213:c791650-791276 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGACACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGACACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0R4J6H3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3LWD6 |