Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 709450..710042 | Replicon | chromosome |
| Accession | NZ_CP072900 | ||
| Organism | Bartonella henselae strain G-5436 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A829Z6B5 |
| Locus tag | KAE71_RS03220 | Protein ID | WP_034447446.1 |
| Coordinates | 709450..709650 (+) | Length | 67 a.a. |
Antitoxin (Protein)
| Gene name | hicA | Uniprot ID | A0A840E534 |
| Locus tag | KAE71_RS03225 | Protein ID | WP_011180290.1 |
| Coordinates | 709647..710042 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE71_RS03175 (KAE71_03160) | 704747..705223 | + | 477 | WP_011180299.1 | hypothetical protein | - |
| KAE71_RS03180 (KAE71_03165) | 705216..705563 | + | 348 | WP_011180298.1 | DUF1376 domain-containing protein | - |
| KAE71_RS03185 (KAE71_03170) | 705553..706665 | + | 1113 | WP_011180297.1 | DUF1376 domain-containing protein | - |
| KAE71_RS03190 (KAE71_03175) | 706658..707077 | + | 420 | WP_038525124.1 | hypothetical protein | - |
| KAE71_RS03195 (KAE71_03180) | 707242..707568 | + | 327 | WP_034447437.1 | hypothetical protein | - |
| KAE71_RS03200 (KAE71_03185) | 707610..707903 | - | 294 | WP_034447441.1 | HigA family addiction module antitoxin | - |
| KAE71_RS03205 (KAE71_03190) | 707920..708201 | - | 282 | WP_011180826.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE71_RS03210 (KAE71_03195) | 708392..708838 | + | 447 | WP_011180293.1 | single-stranded DNA-binding protein | - |
| KAE71_RS03215 (KAE71_03200) | 708849..709385 | + | 537 | WP_034447444.1 | hypothetical protein | - |
| KAE71_RS03220 (KAE71_03205) | 709450..709650 | + | 201 | WP_034447446.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KAE71_RS03225 (KAE71_03210) | 709647..710042 | + | 396 | WP_011180290.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KAE71_RS03230 (KAE71_03215) | 710515..710835 | + | 321 | WP_011180288.1 | hypothetical protein | - |
| KAE71_RS03235 (KAE71_03220) | 710839..711417 | + | 579 | WP_011180287.1 | hypothetical protein | - |
| KAE71_RS03240 (KAE71_03225) | 712014..712556 | + | 543 | WP_011180285.1 | phage antirepressor Ant | - |
| KAE71_RS03245 (KAE71_03230) | 712588..713427 | + | 840 | WP_011180284.1 | antA/AntB antirepressor family protein | - |
| KAE71_RS03250 (KAE71_03235) | 713444..713959 | + | 516 | WP_011180283.1 | phage antirepressor Ant | - |
| KAE71_RS03255 (KAE71_03240) | 714019..714777 | + | 759 | WP_011180282.1 | phage antirepressor Ant | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 690729..757937 | 67208 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 67 a.a. Molecular weight: 7492.81 Da Isoelectric Point: 10.9914
>T199127 WP_034447446.1 NZ_CP072900:709450-709650 [Bartonella henselae]
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
Download Length: 201 bp
>T199127 NZ_CP097213:715737-716033 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14718.71 Da Isoelectric Point: 4.3191
>AT199127 WP_011180290.1 NZ_CP072900:709647-710042 [Bartonella henselae]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
Download Length: 396 bp
>AT199127 NZ_CP097213:716035-716430 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829Z6B5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A840E534 |