Detailed information of TA system TA199126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 304201..304680
• Replicon: chromosome
• Accession: NZ_CP072900
• Organism: Bartonella henselae strain G-5436

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KAE71_RS01460
• Protein ID: WP_236087019.1
• Coordinates: 304201..304353 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A829YZI5
• Locus tag: KAE71_RS01465
• Protein ID: WP_034447857.1
• Coordinates: 304453..304680 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE71_RS01440 (KAE71_01430)	301480..302619	-	1140	WP_049784545.1	phage terminase large subunit	-
KAE71_RS01445 (KAE71_01435)	302600..302926	-	327	WP_011180626.1	hypothetical protein	-
KAE71_RS01450 (KAE71_01440)	303225..303683	+	459	WP_011180624.1	hypothetical protein	-
KAE71_RS01455	303779..304171	+	393	WP_223396448.1	hypothetical protein	-
KAE71_RS01460	304201..304353	-	153	WP_236087019.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAE71_RS01465 (KAE71_01450)	304453..304680	-	228	WP_034447857.1	DUF6290 family protein	Antitoxin
KAE71_RS01470 (KAE71_01455)	304777..305271	-	495	WP_011180825.1	hypothetical protein	-
KAE71_RS01475 (KAE71_01460)	305325..305771	-	447	WP_011180617.1	single-stranded DNA-binding protein	-
KAE71_RS01480 (KAE71_01465)	305962..306243	+	282	WP_011180826.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KAE71_RS01485 (KAE71_01470)	306260..306553	+	294	WP_034447441.1	HigA family addiction module antitoxin	-
KAE71_RS01490 (KAE71_01475)	306595..306921	-	327	WP_011180827.1	hypothetical protein	-
KAE71_RS01500 (KAE71_01485)	307496..307801	-	306	WP_011180828.1	ETC complex I subunit	-
KAE71_RS01510 (KAE71_01495)	308795..309484	-	690	WP_011180829.1	DnaA regulatory inactivator HdaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-48)

Antitoxin

• Protein of unknown function DUF6290 (2-71)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5819.95 Da
• Isoelectric Point: 10.3747

>T199126 WP_236087019.1 NZ_CP072900:c304353-304201 [Bartonella henselae]
VRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAVGHRKNIYKG

Nucleotide

• Length: 153 bp

>T199126 NZ_CP097213:651162-651476 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8714.77 Da
• Isoelectric Point: 4.8780

>AT199126 WP_034447857.1 NZ_CP072900:c304680-304453 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRKGEGTFYSSEEVRKELGLDD

Nucleotide

• Length: 228 bp

>AT199126 NZ_CP097213:651473-651889 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A829YZI5