Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 270352..270941 Replicon chromosome
Accession NZ_CP072900
Organism Bartonella henselae strain G-5436

Toxin (Protein)


Gene name pemK Uniprot ID X5M710
Locus tag KAE71_RS01250 Protein ID WP_011180620.1
Coordinates 270352..270684 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A829Z4P4
Locus tag KAE71_RS01255 Protein ID WP_034448603.1
Coordinates 270684..270941 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE71_RS01220 (KAE71_01205) 266857..268182 - 1326 WP_011180823.1 phage terminase large subunit -
KAE71_RS01225 (KAE71_01210) 268163..268489 - 327 WP_011180626.1 hypothetical protein -
KAE71_RS01230 (KAE71_01215) 268788..269246 + 459 WP_011180624.1 hypothetical protein -
KAE71_RS01235 269342..269734 + 393 WP_075320637.1 hypothetical protein -
KAE71_RS01240 (KAE71_01220) 269764..270033 - 270 WP_011180622.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAE71_RS01245 (KAE71_01225) 270017..270244 - 228 WP_007346764.1 DUF6290 family protein -
KAE71_RS01250 (KAE71_01230) 270352..270684 - 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KAE71_RS01255 (KAE71_01235) 270684..270941 - 258 WP_034448603.1 antitoxin Antitoxin
KAE71_RS01260 (KAE71_01240) 271022..271516 - 495 WP_059443338.1 hypothetical protein -
KAE71_RS01265 (KAE71_01245) 271570..272016 - 447 WP_011180617.1 single-stranded DNA-binding protein -
KAE71_RS01270 (KAE71_01250) 272228..272518 + 291 WP_011180616.1 hypothetical protein -
KAE71_RS01275 (KAE71_01255) 272515..272787 + 273 WP_011180615.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
KAE71_RS01280 (KAE71_01260) 272978..273295 - 318 Protein_246 hypothetical protein -
KAE71_RS01285 (KAE71_01265) 273477..273926 - 450 WP_223396434.1 hypothetical protein -
KAE71_RS01290 (KAE71_01270) 273847..275097 - 1251 WP_011180612.1 DUF1376 domain-containing protein -
KAE71_RS01295 (KAE71_01275) 275087..275566 - 480 WP_011180611.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 243859..283981 40122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11865.88 Da        Isoelectric Point: 10.5590

>T199124 WP_011180620.1 NZ_CP072900:c270684-270352 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT

Download         Length: 333 bp

>T199124 NZ_CP097213:183504-183611 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9381.71 Da        Isoelectric Point: 4.2101

>AT199124 WP_034448603.1 NZ_CP072900:c270941-270684 [Bartonella henselae]
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLVVKPQTFPSYTLDELLAQCNPSDDFADEDMEWFDAKPV
GRELL

Download         Length: 258 bp

>AT199124 NZ_CP097213:c183456-183390 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067W4K9

Antitoxin

Source ID Structure
AlphaFold DB A0A829Z4P4

References