Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemK-pasA/PRK09812-HTH |
| Location | 270017..270684 | Replicon | chromosome |
| Accession | NZ_CP072900 | ||
| Organism | Bartonella henselae strain G-5436 | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | X5M710 |
| Locus tag | KAE71_RS01250 | Protein ID | WP_011180620.1 |
| Coordinates | 270352..270684 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | N6VJG4 |
| Locus tag | KAE71_RS01245 | Protein ID | WP_007346764.1 |
| Coordinates | 270017..270244 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE71_RS01220 (KAE71_01205) | 266857..268182 | - | 1326 | WP_011180823.1 | phage terminase large subunit | - |
| KAE71_RS01225 (KAE71_01210) | 268163..268489 | - | 327 | WP_011180626.1 | hypothetical protein | - |
| KAE71_RS01230 (KAE71_01215) | 268788..269246 | + | 459 | WP_011180624.1 | hypothetical protein | - |
| KAE71_RS01235 | 269342..269734 | + | 393 | WP_075320637.1 | hypothetical protein | - |
| KAE71_RS01240 (KAE71_01220) | 269764..270033 | - | 270 | WP_011180622.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE71_RS01245 (KAE71_01225) | 270017..270244 | - | 228 | WP_007346764.1 | DUF6290 family protein | Antitoxin |
| KAE71_RS01250 (KAE71_01230) | 270352..270684 | - | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| KAE71_RS01255 (KAE71_01235) | 270684..270941 | - | 258 | WP_034448603.1 | antitoxin | - |
| KAE71_RS01260 (KAE71_01240) | 271022..271516 | - | 495 | WP_059443338.1 | hypothetical protein | - |
| KAE71_RS01265 (KAE71_01245) | 271570..272016 | - | 447 | WP_011180617.1 | single-stranded DNA-binding protein | - |
| KAE71_RS01270 (KAE71_01250) | 272228..272518 | + | 291 | WP_011180616.1 | hypothetical protein | - |
| KAE71_RS01275 (KAE71_01255) | 272515..272787 | + | 273 | WP_011180615.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| KAE71_RS01280 (KAE71_01260) | 272978..273295 | - | 318 | Protein_246 | hypothetical protein | - |
| KAE71_RS01285 (KAE71_01265) | 273477..273926 | - | 450 | WP_223396434.1 | hypothetical protein | - |
| KAE71_RS01290 (KAE71_01270) | 273847..275097 | - | 1251 | WP_011180612.1 | DUF1376 domain-containing protein | - |
| KAE71_RS01295 (KAE71_01275) | 275087..275566 | - | 480 | WP_011180611.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 243859..283981 | 40122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11865.88 Da Isoelectric Point: 10.5590
>T199123 WP_011180620.1 NZ_CP072900:c270684-270352 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
Download Length: 333 bp
>T199123 NZ_CP097211:3957-4307 [Aeromonas caviae]
ATGTGGACAGTAAAAACGACCTCTCTATTCGATGTCTGGTTTGATGAACAAGACGAGGCCACGCAGGAGAAGGTTTTGGC
TGGGTTGCTTGCCTTGGCACAGGGCGGTCCATCGGTAGGGCGACCCTTAGTTGATACCATCAAGGGATCTCGCTTTACGA
ACCTCAAAGAGCTGAGAGTTCAGCACCAGGGGGAGCCGCTACGAGCGTTCTTTGCTTTTGACCCGTTGCGGCAAGCCATC
GTGTTGTGTGCTGGCAATAAGGGCGGTAACGATAAGCGGTTTTACAAAGAGATGTTGCCGGTCGCTGAGGCGGAATACGC
CAGGCACTTAACTGAGTTGGAGGTAGGTTAA
ATGTGGACAGTAAAAACGACCTCTCTATTCGATGTCTGGTTTGATGAACAAGACGAGGCCACGCAGGAGAAGGTTTTGGC
TGGGTTGCTTGCCTTGGCACAGGGCGGTCCATCGGTAGGGCGACCCTTAGTTGATACCATCAAGGGATCTCGCTTTACGA
ACCTCAAAGAGCTGAGAGTTCAGCACCAGGGGGAGCCGCTACGAGCGTTCTTTGCTTTTGACCCGTTGCGGCAAGCCATC
GTGTTGTGTGCTGGCAATAAGGGCGGTAACGATAAGCGGTTTTACAAAGAGATGTTGCCGGTCGCTGAGGCGGAATACGC
CAGGCACTTAACTGAGTTGGAGGTAGGTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8742.78 Da Isoelectric Point: 4.8780
>AT199123 WP_007346764.1 NZ_CP072900:c270244-270017 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
Download Length: 228 bp
>AT199123 NZ_CP097211:4307-4609 [Aeromonas caviae]
ATGGGAAGAACACTGAATGAGATGCTGTCCTCCCGCTCGGTGGATAGTCTGCAGCGGATCCAGGAGATGGCTAACGAGCT
GCTGCTGGAGGTGCGCTTGCAAGCGCTGCGTGAAGAGTTGGAAGTGTCCCAGGTGGAGTTGGCCTCTGCCCTTGGCATCA
GCCAACCGGCCGTTGTGGCGATGGAGCAGCGGGGGAATGATATCAAGCTATCCACCATGAAGCGTTACGTGGAAGCAATG
GGTGGGAAGCTGCGTGTTGATGTAGAGCTTCCTACAGGGAGGCATGTCGGTTTCAACGTGTGA
ATGGGAAGAACACTGAATGAGATGCTGTCCTCCCGCTCGGTGGATAGTCTGCAGCGGATCCAGGAGATGGCTAACGAGCT
GCTGCTGGAGGTGCGCTTGCAAGCGCTGCGTGAAGAGTTGGAAGTGTCCCAGGTGGAGTTGGCCTCTGCCCTTGGCATCA
GCCAACCGGCCGTTGTGGCGATGGAGCAGCGGGGGAATGATATCAAGCTATCCACCATGAAGCGTTACGTGGAAGCAATG
GGTGGGAAGCTGCGTGTTGATGTAGAGCTTCCTACAGGGAGGCATGTCGGTTTCAACGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W4K9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | N6VJG4 |