199122

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 269764..270244 Replicon chromosome
Accession NZ_CP072900
Organism Bartonella henselae strain G-5436

Toxin (Protein)


Gene name pasB Uniprot ID A0A067WDE7
Locus tag KAE71_RS01240 Protein ID WP_011180622.1
Coordinates 269764..270033 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID N6VJG4
Locus tag KAE71_RS01245 Protein ID WP_007346764.1
Coordinates 270017..270244 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE71_RS01215 (KAE71_01200) 264818..266872 - 2055 WP_011180822.1 portal protein -
KAE71_RS01220 (KAE71_01205) 266857..268182 - 1326 WP_011180823.1 phage terminase large subunit -
KAE71_RS01225 (KAE71_01210) 268163..268489 - 327 WP_011180626.1 hypothetical protein -
KAE71_RS01230 (KAE71_01215) 268788..269246 + 459 WP_011180624.1 hypothetical protein -
KAE71_RS01235 269342..269734 + 393 WP_075320637.1 hypothetical protein -
KAE71_RS01240 (KAE71_01220) 269764..270033 - 270 WP_011180622.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KAE71_RS01245 (KAE71_01225) 270017..270244 - 228 WP_007346764.1 DUF6290 family protein Antitoxin
KAE71_RS01250 (KAE71_01230) 270352..270684 - 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin -
KAE71_RS01255 (KAE71_01235) 270684..270941 - 258 WP_034448603.1 antitoxin -
KAE71_RS01260 (KAE71_01240) 271022..271516 - 495 WP_059443338.1 hypothetical protein -
KAE71_RS01265 (KAE71_01245) 271570..272016 - 447 WP_011180617.1 single-stranded DNA-binding protein -
KAE71_RS01270 (KAE71_01250) 272228..272518 + 291 WP_011180616.1 hypothetical protein -
KAE71_RS01275 (KAE71_01255) 272515..272787 + 273 WP_011180615.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
KAE71_RS01280 (KAE71_01260) 272978..273295 - 318 Protein_246 hypothetical protein -
KAE71_RS01285 (KAE71_01265) 273477..273926 - 450 WP_223396434.1 hypothetical protein -
KAE71_RS01290 (KAE71_01270) 273847..275097 - 1251 WP_011180612.1 DUF1376 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 243859..283981 40122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10495.44 Da        Isoelectric Point: 10.2009

>T199122 WP_011180622.1 NZ_CP072900:c270033-269764 [Bartonella henselae]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAV
GHRKNIYKG

Download         Length: 270 bp

>T199122 NZ_CP097209:c4384665-4383346 [Aeromonas caviae]
ATGGCTGACCTGGATGTCTACATGAATGGGTACAAGGTGGGCGTTTTCAGCCGTGCTGTCACCGGCGCCCATGCATTCCA
ATACGCTGAGACCTGGCTTAATCAGACCGGCAGCCGTCCTATATCACTTTCCATGCCCTTGCGGCGACAGCCTTATCGGG
GTGATGAGGCCTACAACTTCTTCGATAACCTATTGCCGGATAACCCGGAGATACGAAACCGGATCCTGGCCCGCTATCAC
GCAGACTCAACCCAGCCCTTCGACCTTTTGGCACGAGTCGGTGCAGATACTGTTGGCGCGCTACAACTGCTACCCAAAGG
TGCCGCGCCGGGTGACATTCGCACCATCGACTACAAAGCATTGTCTGACCAAGAACTGGCCAAGATACTCACAGGCTACA
AGGCTGGCGCGCCTTTGGGCATGATTGAGGACATTGAGGACTTCCGCATCTCCTTGGCAGGAGCCCAGGAAAAAACCGCC
CTGCTGTTCAAAGATGGTCGCTGGAGCCAACCCAAAGGCACCACGCCTACAACCCATATCCTCAAGTTGCCTATCGGCAA
GATAGAGAGCCACTCATACAGCCTCGATTTGTCAGACAGCGTCGAAAACGAATTTCTCTGCACCCTGCTGGCAAAAGAGT
TCGGTTTACCGGTCCCCCACTGCTTTATGGTGCGCCTTGATGACATCAAAGCCTTGGCCGTGGAACGTTTTGACCGCAGG
TATGCCTCGGACGGTAGTTGGATCATGCGGCTACCCCAGGAAGATTTTTGCCAAGTACTGAATGTTCCGTCAGCACGGAA
ATACGAAAATCAGGGTGGCCCAGGGATCGGCGAGATAATGTACTACCTGCTGGGATCAGCCAATGCAGAGCAGGATCGCT
ACCACTTCATGAAGGCACAAGTCTTGTTCTGGCTGCTGGCAGCCACCGATGGCCACGCCAAGAACTTCTCGGTATTCATT
GAGCCACAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTACCCAGTATTTGGCGGCCGAGGCCTCAA
CCGCAGGGACGCCAAGCTCGCTATGGGTCTGGCTAGCAGCAAGGGTAAGAAGTACGCCATTGAGCAGATATTCCCACGCC
ACTTCTTCCAAACGGCCAAAGCGGTGGGATTCGAGCGCTCCGCCATGGAAGGGATCCTGACAGAACTGGCCGGCGCCGTT
GATGCCGTTATTGAGCGCGTGACACAGCAGTTACCGGCGGGCTTCCCTGCTGCGATCAGCAGCGCTATTTTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAACGGGCTGGGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8742.78 Da        Isoelectric Point: 4.8780

>AT199122 WP_007346764.1 NZ_CP072900:c270244-270017 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Download         Length: 228 bp

>AT199122 NZ_CP097209:c4384916-4384665 [Aeromonas caviae]
ATGAAGATCACCAATGCCAAGCAGCTCAGTGCCTACCTGCGAGATGTTCGTCTCTCTGCAGATCTGTCCCAGGGAAAAGT
GGCCAGCAAAGTGGGGATCCGCCAGGACACGGTATCCAGCTTTGAGCTCCAGCCGGGCACAACCAAGCTGGAAACCTTCT
TCAAGATCCTGTCAGCACTGGATCTGGAACTAGAAGTGAAACCCAAAGGCAGCGACCCCCAAAGCCCTGATGGCTGGAAA
GAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067WDE7

Antitoxin

Source ID Structure
AlphaFold DB N6VJG4

References