Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 741781..742312 Replicon chromosome
Accession NZ_CP072899
Organism Bartonella henselae strain 88-64 Oklahoma

Toxin (Protein)


Gene name relE Uniprot ID X5M5T9
Locus tag KAE77_RS03505 Protein ID WP_011180281.1
Coordinates 741781..742062 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A0H3LWD6
Locus tag KAE77_RS03510 Protein ID WP_011180280.1
Coordinates 742049..742312 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE77_RS03470 (KAE77_03430) 737201..737521 + 321 WP_011180288.1 hypothetical protein -
KAE77_RS03475 (KAE77_03435) 737525..738103 + 579 WP_011180287.1 hypothetical protein -
KAE77_RS03480 (KAE77_03440) 738700..739242 + 543 WP_011180285.1 phage antirepressor Ant -
KAE77_RS03485 (KAE77_03445) 739274..740113 + 840 WP_011180284.1 antA/AntB antirepressor family protein -
KAE77_RS03490 (KAE77_03450) 740130..740645 + 516 WP_011180283.1 phage antirepressor Ant -
KAE77_RS03495 (KAE77_03455) 740705..741463 + 759 WP_011180282.1 phage antirepressor Ant -
KAE77_RS03500 (KAE77_03460) 741460..741738 + 279 WP_011180242.1 hypothetical protein -
KAE77_RS03505 (KAE77_03465) 741781..742062 - 282 WP_011180281.1 type II toxin-antitoxin system YafQ family toxin Toxin
KAE77_RS03510 (KAE77_03470) 742049..742312 - 264 WP_011180280.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KAE77_RS03515 (KAE77_03475) 742722..743018 - 297 WP_011180278.1 HigA family addiction module antitoxin -
KAE77_RS03520 (KAE77_03480) 743035..743349 - 315 WP_011180277.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAE77_RS03525 (KAE77_03485) 743412..743993 + 582 WP_011180276.1 hypothetical protein -
KAE77_RS03530 (KAE77_03490) 743986..745914 + 1929 WP_011180275.1 phage terminase large subunit family protein -
KAE77_RS03535 (KAE77_03495) 745918..746166 + 249 WP_011180274.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 712997..784623 71626


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11106.85 Da        Isoelectric Point: 10.3380

>T199120 WP_011180281.1 NZ_CP072899:c742062-741781 [Bartonella henselae]
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL

Download         Length: 282 bp

>T199120 NZ_CP097208:c1293672-1292926 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
AGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTAGTAGGCGCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGGAGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGGACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9565.81 Da        Isoelectric Point: 4.1403

>AT199120 WP_011180280.1 NZ_CP072899:c742312-742049 [Bartonella henselae]
MATSRMVQARVPEEIQNVASQVIQASGLTVSDVVRVLMTRIAQDKAIPSVLFQPNAETIAAFAEVDEGNLKKFHSVDELF
DDLYADD

Download         Length: 264 bp

>AT199120 NZ_CP097208:c1292925-1292755 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R4J6H3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LWD6

References