Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 736136..736728 | Replicon | chromosome |
| Accession | NZ_CP072899 | ||
| Organism | Bartonella henselae strain 88-64 Oklahoma | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A829Z6B5 |
| Locus tag | KAE77_RS03460 | Protein ID | WP_034447446.1 |
| Coordinates | 736136..736336 (+) | Length | 67 a.a. |
Antitoxin (Protein)
| Gene name | hicA | Uniprot ID | A0A840E534 |
| Locus tag | KAE77_RS03465 | Protein ID | WP_011180290.1 |
| Coordinates | 736333..736728 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE77_RS03415 (KAE77_03375) | 731433..731909 | + | 477 | WP_011180299.1 | hypothetical protein | - |
| KAE77_RS03420 (KAE77_03380) | 731902..732249 | + | 348 | WP_011180298.1 | DUF1376 domain-containing protein | - |
| KAE77_RS03425 (KAE77_03385) | 732239..733351 | + | 1113 | WP_011180297.1 | DUF1376 domain-containing protein | - |
| KAE77_RS03430 (KAE77_03390) | 733344..733763 | + | 420 | WP_038525124.1 | hypothetical protein | - |
| KAE77_RS03435 (KAE77_03395) | 733928..734254 | + | 327 | WP_034447437.1 | hypothetical protein | - |
| KAE77_RS03440 (KAE77_03400) | 734296..734589 | - | 294 | WP_034447441.1 | HigA family addiction module antitoxin | - |
| KAE77_RS03445 (KAE77_03405) | 734606..734887 | - | 282 | WP_011180826.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE77_RS03450 (KAE77_03410) | 735078..735524 | + | 447 | WP_011180293.1 | single-stranded DNA-binding protein | - |
| KAE77_RS03455 (KAE77_03415) | 735535..736071 | + | 537 | WP_034447444.1 | hypothetical protein | - |
| KAE77_RS03460 (KAE77_03420) | 736136..736336 | + | 201 | WP_034447446.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KAE77_RS03465 (KAE77_03425) | 736333..736728 | + | 396 | WP_011180290.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KAE77_RS03470 (KAE77_03430) | 737201..737521 | + | 321 | WP_011180288.1 | hypothetical protein | - |
| KAE77_RS03475 (KAE77_03435) | 737525..738103 | + | 579 | WP_011180287.1 | hypothetical protein | - |
| KAE77_RS03480 (KAE77_03440) | 738700..739242 | + | 543 | WP_011180285.1 | phage antirepressor Ant | - |
| KAE77_RS03485 (KAE77_03445) | 739274..740113 | + | 840 | WP_011180284.1 | antA/AntB antirepressor family protein | - |
| KAE77_RS03490 (KAE77_03450) | 740130..740645 | + | 516 | WP_011180283.1 | phage antirepressor Ant | - |
| KAE77_RS03495 (KAE77_03455) | 740705..741463 | + | 759 | WP_011180282.1 | phage antirepressor Ant | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 712997..784623 | 71626 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 67 a.a. Molecular weight: 7492.81 Da Isoelectric Point: 10.9914
>T199119 WP_034447446.1 NZ_CP072899:736136-736336 [Bartonella henselae]
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
Download Length: 201 bp
>T199119 NZ_CP097208:510876-511226 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 132 a.a. Molecular weight: 14718.71 Da Isoelectric Point: 4.3191
>AT199119 WP_011180290.1 NZ_CP072899:736333-736728 [Bartonella henselae]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
Download Length: 396 bp
>AT199119 NZ_CP097208:510589-510870 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829Z6B5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A840E534 |