Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE-RHH
Location 264335..264894 Replicon chromosome
Accession NZ_CP072899
Organism Bartonella henselae strain 88-64 Oklahoma

Toxin (Protein)


Gene name relE Uniprot ID X5M706
Locus tag KAE77_RS01260 Protein ID WP_011180615.1
Coordinates 264622..264894 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID X5LVL8
Locus tag KAE77_RS01255 Protein ID WP_011180616.1
Coordinates 264335..264625 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE77_RS01210 (KAE77_01185) 260274..260603 - 330 WP_236095317.1 hypothetical protein -
KAE77_RS01215 (KAE77_01190) 260957..261322 + 366 WP_236095307.1 hypothetical protein -
KAE77_RS01220 261448..261841 + 394 Protein_234 hypothetical protein -
KAE77_RS01225 (KAE77_01195) 261871..262140 - 270 WP_011180622.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAE77_RS01230 (KAE77_01200) 262124..262351 - 228 WP_007346764.1 DUF6290 family protein -
KAE77_RS01235 (KAE77_01205) 262459..262791 - 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin -
KAE77_RS01240 (KAE77_01210) 262791..263048 - 258 WP_034459411.1 antitoxin -
KAE77_RS01245 (KAE77_01215) 263129..263623 - 495 WP_034448601.1 hypothetical protein -
KAE77_RS01250 (KAE77_01220) 263677..264123 - 447 WP_011180617.1 single-stranded DNA-binding protein -
KAE77_RS01255 (KAE77_01225) 264335..264625 + 291 WP_011180616.1 hypothetical protein Antitoxin
KAE77_RS01260 (KAE77_01230) 264622..264894 + 273 WP_011180615.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
KAE77_RS01265 (KAE77_01235) 265085..265402 - 318 Protein_243 hypothetical protein -
KAE77_RS01270 (KAE77_01240) 265584..265790 - 207 WP_034448620.1 hypothetical protein -
KAE77_RS01275 (KAE77_01245) 265733..265969 - 237 WP_236095319.1 hypothetical protein -
KAE77_RS01280 (KAE77_01250) 265953..267204 - 1252 Protein_246 DUF1376 domain-containing protein -
KAE77_RS01285 (KAE77_01255) 267194..267674 - 481 Protein_247 hypothetical protein -
KAE77_RS01290 (KAE77_01260) 267811..268188 - 378 WP_236095308.1 hypothetical protein -
KAE77_RS01295 268172..268534 - 363 WP_034459412.1 hypothetical protein -
KAE77_RS01300 (KAE77_01270) 268619..268927 + 309 WP_236095309.1 helix-turn-helix transcriptional regulator -
KAE77_RS01305 (KAE77_01275) 269195..269568 + 374 Protein_251 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 235922..313003 77081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10747.75 Da        Isoelectric Point: 11.3976

>T199113 WP_011180615.1 NZ_CP072899:264622-264894 [Bartonella henselae]
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP

Download         Length: 273 bp

>T199113 NZ_CP097190:c4845186-4844269 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11099.43 Da        Isoelectric Point: 4.5837

>AT199113 WP_011180616.1 NZ_CP072899:264335-264625 [Bartonella henselae]
MAETTFTFRVDDALKSEFSQAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS

Download         Length: 291 bp

>AT199113 NZ_CP097190:c4845950-4845192 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATATGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067W4L5

Antitoxin

Source ID Structure
AlphaFold DB A0A067W521

References