Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
| Location | 262459..263048 | Replicon | chromosome |
| Accession | NZ_CP072899 | ||
| Organism | Bartonella henselae strain 88-64 Oklahoma | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | X5M710 |
| Locus tag | KAE77_RS01235 | Protein ID | WP_011180620.1 |
| Coordinates | 262459..262791 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | X5LZ85 |
| Locus tag | KAE77_RS01240 | Protein ID | WP_034459411.1 |
| Coordinates | 262791..263048 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE77_RS01205 (KAE77_01180) | 258967..260293 | - | 1327 | Protein_231 | phage terminase large subunit | - |
| KAE77_RS01210 (KAE77_01185) | 260274..260603 | - | 330 | WP_236095317.1 | hypothetical protein | - |
| KAE77_RS01215 (KAE77_01190) | 260957..261322 | + | 366 | WP_236095307.1 | hypothetical protein | - |
| KAE77_RS01220 | 261448..261841 | + | 394 | Protein_234 | hypothetical protein | - |
| KAE77_RS01225 (KAE77_01195) | 261871..262140 | - | 270 | WP_011180622.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE77_RS01230 (KAE77_01200) | 262124..262351 | - | 228 | WP_007346764.1 | DUF6290 family protein | - |
| KAE77_RS01235 (KAE77_01205) | 262459..262791 | - | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| KAE77_RS01240 (KAE77_01210) | 262791..263048 | - | 258 | WP_034459411.1 | antitoxin | Antitoxin |
| KAE77_RS01245 (KAE77_01215) | 263129..263623 | - | 495 | WP_034448601.1 | hypothetical protein | - |
| KAE77_RS01250 (KAE77_01220) | 263677..264123 | - | 447 | WP_011180617.1 | single-stranded DNA-binding protein | - |
| KAE77_RS01255 (KAE77_01225) | 264335..264625 | + | 291 | WP_011180616.1 | hypothetical protein | - |
| KAE77_RS01260 (KAE77_01230) | 264622..264894 | + | 273 | WP_011180615.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| KAE77_RS01265 (KAE77_01235) | 265085..265402 | - | 318 | Protein_243 | hypothetical protein | - |
| KAE77_RS01270 (KAE77_01240) | 265584..265790 | - | 207 | WP_034448620.1 | hypothetical protein | - |
| KAE77_RS01275 (KAE77_01245) | 265733..265969 | - | 237 | WP_236095319.1 | hypothetical protein | - |
| KAE77_RS01280 (KAE77_01250) | 265953..267204 | - | 1252 | Protein_246 | DUF1376 domain-containing protein | - |
| KAE77_RS01285 (KAE77_01255) | 267194..267674 | - | 481 | Protein_247 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 235922..313003 | 77081 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11865.88 Da Isoelectric Point: 10.5590
>T199112 WP_011180620.1 NZ_CP072899:c262791-262459 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
Download Length: 333 bp
>T199112 NZ_CP097190:c4687867-4687583 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9436.79 Da Isoelectric Point: 4.3536
>AT199112 WP_034459411.1 NZ_CP072899:c263048-262791 [Bartonella henselae]
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLVVKPQTFPSYTLDELLAQCHLSDDFSDEDMEWFDAKPV
GRELL
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLVVKPQTFPSYTLDELLAQCHLSDDFSDEDMEWFDAKPV
GRELL
Download Length: 258 bp
>AT199112 NZ_CP097190:c4688099-4687857 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W4K9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W7K8 |