Detailed information of TA system TA199105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/RelE-RHH
• Location: 276506..277065
• Replicon: chromosome
• Accession: NZ_CP072898
• Organism: Bartonella henselae strain FR96/BK38

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X5M706
• Locus tag: KAE75_RS01310
• Protein ID: WP_011180615.1
• Coordinates: 276793..277065 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: KAE75_RS01305
• Protein ID: WP_034455002.1
• Coordinates: 276506..276796 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE75_RS01260 (KAE75_01230)	272308..272634	-	327	WP_011180626.1	hypothetical protein	-
KAE75_RS01265 (KAE75_01235)	272934..273545	+	612	WP_034454997.1	hypothetical protein	-
KAE75_RS01270	273578..274012	+	435	WP_034454998.1	hypothetical protein	-
KAE75_RS01275	274042..274194	-	153	WP_236093296.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KAE75_RS01280 (KAE75_01245)	274294..274521	-	228	WP_034447857.1	DUF6290 family protein	-
KAE75_RS01285 (KAE75_01250)	274629..274961	-	333	WP_011180620.1	type II toxin-antitoxin system PemK/MazF family toxin	-
KAE75_RS01290 (KAE75_01255)	274961..275218	-	258	WP_034448603.1	antitoxin	-
KAE75_RS01295 (KAE75_01260)	275299..275793	-	495	WP_034455000.1	hypothetical protein	-
KAE75_RS01300 (KAE75_01265)	275847..276293	-	447	WP_034455001.1	single-stranded DNA-binding protein	-
KAE75_RS01305 (KAE75_01270)	276506..276796	+	291	WP_034455002.1	hypothetical protein	Antitoxin
KAE75_RS01310 (KAE75_01275)	276793..277065	+	273	WP_011180615.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
KAE75_RS01315	277256..277573	-	318	Protein_253	hypothetical protein	-
KAE75_RS01320 (KAE75_01285)	277755..278141	-	387	WP_236093292.1	hypothetical protein	-
KAE75_RS01325 (KAE75_01290)	278125..279276	-	1152	WP_034455004.1	DUF1376 domain-containing protein	-
KAE75_RS01330 (KAE75_01295)	279266..279610	-	345	WP_034452646.1	DUF1376 domain-containing protein	-
KAE75_RS01335 (KAE75_01300)	279600..280080	-	481	Protein_257	hypothetical protein	-
KAE75_RS01340 (KAE75_01305)	280219..280578	-	360	WP_011180610.1	hypothetical protein	-
KAE75_RS01345 (KAE75_01310)	280581..280895	-	315	WP_034455005.1	helix-turn-helix transcriptional regulator	-
KAE75_RS01350 (KAE75_01315)	280988..281287	+	300	WP_034455006.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	275299..310531	35232

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10747.75 Da
• Isoelectric Point: 11.3976

>T199105 WP_011180615.1 NZ_CP072898:276793-277065 [Bartonella henselae]
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP

Nucleotide

• Length: 273 bp

>T199105 NZ_CP097186:4806270-4806839 [Rhodococcus sp. GA1]
ATGAGGCGTCTGGATCTGATCGTCGGTCCCAACGGTTCCGGCAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGCGCAGCGTGTTCGTCAATGCGGATGTGATCGCGCGGCAGCGCTGGCCCGACCGGGCGGAGGAGATGTCGTACGAGG
CGGCGCAGCTCGCCGCGGCGGCGCGGGACCGGTTGCTGCGGCAGGGCCGGTCGTTCATTGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGTTGATCGACCGCGCGCACGAGGTGGGGTTCACGGTGGTGCTGCACGTGATGCTGGTGCCCGAGGC
GATGTCGGTGCTGCGTGTACAGCACCGGGTGGCCTCCGGTGGGCATGCGGTGCCCGAGGACAAGATCCGGGCGCGTTATC
GGCGGTTGTGGCCGCTGGTGGCCGAAGCGATCGGCCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGTGCCGGTGGGTGCGGTGCGCTGGCCGGGATGGGCGCCGGCGGCGCTCACCGG
GCTCGGCTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11127.53 Da
• Isoelectric Point: 4.7370

>AT199105 WP_034455002.1 NZ_CP072898:276506-276796 [Bartonella henselae]
MAETTFTFRVDDVLKSEFSQAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVKLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS

Nucleotide

• Length: 291 bp

>AT199105 NZ_CP097186:4805887-4806273 [Rhodococcus sp. GA1]
ATGACGTCATCCACCGACAAGGTCACCCGCTTCGACGCCGAACTCGTCGACAGCGCCATCGCCGAGGGCGGCCGCCAGAA
CCGCACCGGACGCCAGCAACTCGAGTACTGGGCCCGCATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCCCTGCACC
GGGTGCACGAGGCGCTGGCCGGGACACGGGAGCTGAGCGAGCTCACCGCCGCCGAGGGACGGCTGTTCGACGCGGAGATC
GATGCGCGCCTGGCGGACGGGCTGGCCCGCACCGACTACGCCGAGATTCTCGCCGCGCGTGGGGTCACCACGGTGGTGCT
CGACGACGAAGGCCGGCTGGTCGAGCAGCGTCCCGACGGTAGTCGCCGGGTGCTCGACGACGCATGA

Structures

Toxin

• AlphaFold DB: A0A067W4L5