Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 274629..275218 Replicon chromosome
Accession NZ_CP072898
Organism Bartonella henselae strain FR96/BK38

Toxin (Protein)


Gene name pemK Uniprot ID X5M710
Locus tag KAE75_RS01285 Protein ID WP_011180620.1
Coordinates 274629..274961 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A829Z4P4
Locus tag KAE75_RS01290 Protein ID WP_034448603.1
Coordinates 274961..275218 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE75_RS01255 (KAE75_01225) 271188..272327 - 1140 WP_051401522.1 phage terminase large subunit -
KAE75_RS01260 (KAE75_01230) 272308..272634 - 327 WP_011180626.1 hypothetical protein -
KAE75_RS01265 (KAE75_01235) 272934..273545 + 612 WP_034454997.1 hypothetical protein -
KAE75_RS01270 273578..274012 + 435 WP_034454998.1 hypothetical protein -
KAE75_RS01275 274042..274194 - 153 WP_236093296.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAE75_RS01280 (KAE75_01245) 274294..274521 - 228 WP_034447857.1 DUF6290 family protein -
KAE75_RS01285 (KAE75_01250) 274629..274961 - 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KAE75_RS01290 (KAE75_01255) 274961..275218 - 258 WP_034448603.1 antitoxin Antitoxin
KAE75_RS01295 (KAE75_01260) 275299..275793 - 495 WP_034455000.1 hypothetical protein -
KAE75_RS01300 (KAE75_01265) 275847..276293 - 447 WP_034455001.1 single-stranded DNA-binding protein -
KAE75_RS01305 (KAE75_01270) 276506..276796 + 291 WP_034455002.1 hypothetical protein -
KAE75_RS01310 (KAE75_01275) 276793..277065 + 273 WP_011180615.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
KAE75_RS01315 277256..277573 - 318 Protein_253 hypothetical protein -
KAE75_RS01320 (KAE75_01285) 277755..278141 - 387 WP_236093292.1 hypothetical protein -
KAE75_RS01325 (KAE75_01290) 278125..279276 - 1152 WP_034455004.1 DUF1376 domain-containing protein -
KAE75_RS01330 (KAE75_01295) 279266..279610 - 345 WP_034452646.1 DUF1376 domain-containing protein -
KAE75_RS01335 (KAE75_01300) 279600..280080 - 481 Protein_257 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11865.88 Da        Isoelectric Point: 10.5590

>T199104 WP_011180620.1 NZ_CP072898:c274961-274629 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT

Download         Length: 333 bp

>T199104 NZ_CP097186:2563119-2563373 [Rhodococcus sp. GA1]
GTGAACATCACCTTCACCGACGAAGCCTGGGACGACTACCAGTTCTGGATCTCGACCGACAGAAAGCAGCTCGAGCGTGT
CAACGAGCTGATCAGGGATTGCCAACGAGACCCGTACTCGGGGATCGGCAAACCCGAACGGCTCAGACATGCCCTGTCAG
GACTGTGGTCTCGACGTATCGACAAAGAACACCGCCTGGTCTACGAGGTCATCGACGGTGCCCTGGTCATCATCGCCGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9381.71 Da        Isoelectric Point: 4.2101

>AT199104 WP_034448603.1 NZ_CP072898:c275218-274961 [Bartonella henselae]
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLVVKPQTFPSYTLDELLAQCNPSDDFADEDMEWFDAKPV
GRELL

Download         Length: 258 bp

>AT199104 NZ_CP097186:2562874-2563122 [Rhodococcus sp. GA1]
ATGGCTGCCATCACTGCTACCGAAGCGAGAAAAAACTTCTTTCCGCTGCTCGAACAGGTCAACAAGGACCACACCCCTGT
GGAAATCGTATCCAAGCGGGGCAATGCCGTCCTGATGTCGAAGGATGACTACGACGCCATGCTCGAGACCTCGTACCTGA
TGCAGTCTCCGGCCAACGCCCGACGACTGCTCGCCAGCATGCAGAGAGCTCGCGGAGGTGAACACACCGAAAGGGAACTC
ATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067W4K9

Antitoxin

Source ID Structure
AlphaFold DB A0A829Z4P4

References