Detailed information of TA system TA199102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 274042..274521
• Replicon: chromosome
• Accession: NZ_CP072898
• Organism: Bartonella henselae strain FR96/BK38

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KAE75_RS01275
• Protein ID: WP_236093296.1
• Coordinates: 274042..274194 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A829YZI5
• Locus tag: KAE75_RS01280
• Protein ID: WP_034447857.1
• Coordinates: 274294..274521 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE75_RS01255 (KAE75_01225)	271188..272327	-	1140	WP_051401522.1	phage terminase large subunit	-
KAE75_RS01260 (KAE75_01230)	272308..272634	-	327	WP_011180626.1	hypothetical protein	-
KAE75_RS01265 (KAE75_01235)	272934..273545	+	612	WP_034454997.1	hypothetical protein	-
KAE75_RS01270	273578..274012	+	435	WP_034454998.1	hypothetical protein	-
KAE75_RS01275	274042..274194	-	153	WP_236093296.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAE75_RS01280 (KAE75_01245)	274294..274521	-	228	WP_034447857.1	DUF6290 family protein	Antitoxin
KAE75_RS01285 (KAE75_01250)	274629..274961	-	333	WP_011180620.1	type II toxin-antitoxin system PemK/MazF family toxin	-
KAE75_RS01290 (KAE75_01255)	274961..275218	-	258	WP_034448603.1	antitoxin	-
KAE75_RS01295 (KAE75_01260)	275299..275793	-	495	WP_034455000.1	hypothetical protein	-
KAE75_RS01300 (KAE75_01265)	275847..276293	-	447	WP_034455001.1	single-stranded DNA-binding protein	-
KAE75_RS01305 (KAE75_01270)	276506..276796	+	291	WP_034455002.1	hypothetical protein	-
KAE75_RS01310 (KAE75_01275)	276793..277065	+	273	WP_011180615.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
KAE75_RS01315	277256..277573	-	318	Protein_253	hypothetical protein	-
KAE75_RS01320 (KAE75_01285)	277755..278141	-	387	WP_236093292.1	hypothetical protein	-
KAE75_RS01325 (KAE75_01290)	278125..279276	-	1152	WP_034455004.1	DUF1376 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-48)

Antitoxin

• Protein of unknown function DUF6290 (2-71)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5877.98 Da
• Isoelectric Point: 10.1433

>T199102 WP_236093296.1 NZ_CP072898:c274194-274042 [Bartonella henselae]
VRVIDKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAVGHRKNIYKG

Nucleotide

• Length: 153 bp

>T199102 NZ_CP097186:c1829205-1828927 [Rhodococcus sp. GA1]
ATGAGCACGCCGGACCACCCGTATCGGCTGGTGATGGCGAGGTCGGCTGCACGCGCCATGGCGAGGTCGTTGCCGGAGAA
AGTAGCAACTGCGGTATACGAGTTCGTCACAGGACCCCTTCTCGAGAATCCGAAGCGGGTGGGGAAGCCGTTGAATCCGC
CTCTTGCGCCGGCGTACAGCGCCCGGCGAGGTGAATATCGCGTCCTGTATCTGATCGATGATGCGAACCGCACGGTCGAG
GTCACCGCGATTTCGCACCGTGCCGATGCGTATCGATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8714.77 Da
• Isoelectric Point: 4.8780

>AT199102 WP_034447857.1 NZ_CP072898:c274521-274294 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRKGEGTFYSSEEVRKELGLDD

Nucleotide

• Length: 228 bp

>AT199102 NZ_CP097186:c1829486-1829202 [Rhodococcus sp. GA1]
ATGACGACTCTTCCTGTTGCCGACGCGCGGGCGCAATTGTCACGACTGGTCGATGAGGCCGAGCGCACACACGAGCGATT
CGAGATCACCCGCAACGGGCACCGCGCCGCGGTGCTTCTCGGTGCCGACGATTACGACGCGATGCAGGAGACGATCGCGG
TGTTGTCGGATACGGATCTGCTGCGGGCGCACGTCGAGGGCCGAACGGAGGTCGAGTCGGGAGACGTCGTCGATGTACAG
GAATTGACGCAGCTGATGCGTGATGCTCGGTCGTCCGAGGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A829YZI5