Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1602328..1602920 | Replicon | chromosome |
| Accession | NZ_CP072897 | ||
| Organism | Bartonella henselae strain FR96/BK3 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A829Z6B5 |
| Locus tag | KAE70_RS06915 | Protein ID | WP_034447446.1 |
| Coordinates | 1602720..1602920 (-) | Length | 67 a.a. |
Antitoxin (Protein)
| Gene name | hicA | Uniprot ID | A0A840E534 |
| Locus tag | KAE70_RS06910 | Protein ID | WP_011180290.1 |
| Coordinates | 1602328..1602723 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE70_RS06885 (KAE70_06665) | 1598071..1598616 | - | 546 | WP_236095365.1 | antA/AntB antirepressor family protein | - |
| KAE70_RS06890 (KAE70_06670) | 1598915..1599460 | - | 546 | Protein_1344 | antA/AntB antirepressor family protein | - |
| KAE70_RS06895 (KAE70_06675) | 1600035..1600625 | - | 591 | WP_038487063.1 | antA/AntB antirepressor family protein | - |
| KAE70_RS06900 (KAE70_06680) | 1600953..1601531 | - | 579 | WP_038487065.1 | hypothetical protein | - |
| KAE70_RS06905 (KAE70_06685) | 1601535..1601855 | - | 321 | WP_038487067.1 | hypothetical protein | - |
| KAE70_RS06910 (KAE70_06690) | 1602328..1602723 | - | 396 | WP_011180290.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KAE70_RS06915 (KAE70_06695) | 1602720..1602920 | - | 201 | WP_034447446.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KAE70_RS06920 (KAE70_06700) | 1602985..1603521 | - | 537 | WP_236095366.1 | hypothetical protein | - |
| KAE70_RS06925 (KAE70_06705) | 1603532..1603978 | - | 447 | WP_236095434.1 | single-stranded DNA-binding protein | - |
| KAE70_RS06930 (KAE70_06710) | 1604169..1604450 | + | 282 | WP_011180826.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE70_RS06935 (KAE70_06715) | 1604467..1604760 | + | 294 | WP_034447441.1 | HigA family addiction module antitoxin | - |
| KAE70_RS06940 (KAE70_06720) | 1604802..1605127 | - | 326 | Protein_1354 | hypothetical protein | - |
| KAE70_RS06945 (KAE70_06725) | 1605292..1605711 | - | 420 | WP_038525124.1 | hypothetical protein | - |
| KAE70_RS06950 (KAE70_06730) | 1605704..1606816 | - | 1113 | WP_011180297.1 | DUF1376 domain-containing protein | - |
| KAE70_RS06955 (KAE70_06735) | 1606806..1607156 | - | 351 | WP_082252506.1 | DUF1376 domain-containing protein | - |
| KAE70_RS06960 (KAE70_06740) | 1607146..1607625 | - | 480 | WP_236095435.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1551933..1622033 | 70100 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 67 a.a. Molecular weight: 7492.81 Da Isoelectric Point: 10.9914
>T199101 WP_034447446.1 NZ_CP072897:c1602920-1602720 [Bartonella henselae]
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
Download Length: 201 bp
>T199101 NZ_CP097183:c21955-21722 [Escherichia coli]
ATTCGTGAGTACATTGCGGAGCAGAACCTGATGGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCT
GGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTGTGGAAGGTGCCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGG
TTTATGAGGTCGATAGCCAGTGGGAAAAAGTGTATATCCTGCGTGTATTGCATACAACACAGAAGTGGCCATAG
ATTCGTGAGTACATTGCGGAGCAGAACCTGATGGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCT
GGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTGTGGAAGGTGCCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGG
TTTATGAGGTCGATAGCCAGTGGGAAAAAGTGTATATCCTGCGTGTATTGCATACAACACAGAAGTGGCCATAG
Antitoxin
Download Length: 132 a.a. Molecular weight: 14718.71 Da Isoelectric Point: 4.3191
>AT199101 WP_011180290.1 NZ_CP072897:c1602723-1602328 [Bartonella henselae]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
Download Length: 396 bp
>AT199101 NZ_CP097183:c22269-22000 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCAAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGATAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCAAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829Z6B5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A840E534 |