Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-dinJ/YafQ-RelB |
| Location | 1596432..1596963 | Replicon | chromosome |
| Accession | NZ_CP072897 | ||
| Organism | Bartonella henselae strain FR96/BK3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | X5M5T9 |
| Locus tag | KAE70_RS06870 | Protein ID | WP_011180281.1 |
| Coordinates | 1596682..1596963 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | X5M3D1 |
| Locus tag | KAE70_RS06865 | Protein ID | WP_038487057.1 |
| Coordinates | 1596432..1596695 (+) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE70_RS06840 (KAE70_06620) | 1592568..1592816 | - | 249 | WP_038487052.1 | phage related protein | - |
| KAE70_RS06845 (KAE70_06625) | 1592820..1594751 | - | 1932 | WP_082251725.1 | phage terminase large subunit family protein | - |
| KAE70_RS06850 (KAE70_06630) | 1594782..1595333 | - | 552 | WP_034454327.1 | hypothetical protein | - |
| KAE70_RS06855 (KAE70_06635) | 1595396..1595710 | + | 315 | WP_038487056.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE70_RS06860 (KAE70_06640) | 1595727..1596023 | + | 297 | WP_034454130.1 | HigA family addiction module antitoxin | - |
| KAE70_RS06865 (KAE70_06645) | 1596432..1596695 | + | 264 | WP_038487057.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| KAE70_RS06870 (KAE70_06650) | 1596682..1596963 | + | 282 | WP_011180281.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| KAE70_RS06875 (KAE70_06655) | 1597006..1597284 | - | 279 | WP_038487059.1 | hypothetical protein | - |
| KAE70_RS06880 (KAE70_06660) | 1597281..1598039 | - | 759 | WP_038487061.1 | antA/AntB antirepressor family protein | - |
| KAE70_RS06885 (KAE70_06665) | 1598071..1598616 | - | 546 | WP_236095365.1 | antA/AntB antirepressor family protein | - |
| KAE70_RS06890 (KAE70_06670) | 1598915..1599460 | - | 546 | Protein_1344 | antA/AntB antirepressor family protein | - |
| KAE70_RS06895 (KAE70_06675) | 1600035..1600625 | - | 591 | WP_038487063.1 | antA/AntB antirepressor family protein | - |
| KAE70_RS06900 (KAE70_06680) | 1600953..1601531 | - | 579 | WP_038487065.1 | hypothetical protein | - |
| KAE70_RS06905 (KAE70_06685) | 1601535..1601855 | - | 321 | WP_038487067.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1551933..1622033 | 70100 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11106.85 Da Isoelectric Point: 10.3380
>T199100 WP_011180281.1 NZ_CP072897:1596682-1596963 [Bartonella henselae]
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL
Download Length: 282 bp
>T199100 NZ_CP097183:9251-9631 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
Antitoxin
Download Length: 88 a.a. Molecular weight: 9623.89 Da Isoelectric Point: 4.1403
>AT199100 WP_038487057.1 NZ_CP072897:1596432-1596695 [Bartonella henselae]
MATSRMVQARVPEEIQNVASQVIQASGLSVSDVVRVLMTRIAQDKAIPPFLFQPNAETIAAFAELDEGNLKKFHSVDELF
DDLYADD
MATSRMVQARVPEEIQNVASQVIQASGLSVSDVVRVLMTRIAQDKAIPPFLFQPNAETIAAFAELDEGNLKKFHSVDELF
DDLYADD
Download Length: 264 bp
>AT199100 NZ_CP097183:9030-9251 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0R4J6H3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | X5M3D1 |