Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1562730..1563277 Replicon chromosome
Accession NZ_CP072897
Organism Bartonella henselae strain FR96/BK3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KAE70_RS06640 Protein ID WP_082251260.1
Coordinates 1562954..1563277 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KAE70_RS06635 Protein ID WP_019224016.1
Coordinates 1562730..1562954 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE70_RS06595 (KAE70_06380) 1559140..1559961 + 822 WP_236095359.1 antA/AntB antirepressor family protein -
KAE70_RS06600 (KAE70_06385) 1559989..1560537 + 549 WP_236095360.1 antA/AntB antirepressor family protein -
KAE70_RS06605 (KAE70_06390) 1560658..1560933 + 276 WP_011180235.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
KAE70_RS06610 (KAE70_06395) 1560946..1561236 + 291 WP_011180236.1 type II toxin-antitoxin system YafQ family toxin -
KAE70_RS06615 (KAE70_06400) 1561359..1561571 - 213 WP_034447463.1 hypothetical protein -
KAE70_RS06620 1561564..1561767 - 204 WP_034447462.1 hypothetical protein -
KAE70_RS06625 (KAE70_06405) 1561700..1561927 - 228 WP_038487030.1 hypothetical protein -
KAE70_RS06630 (KAE70_06410) 1561924..1562586 - 663 WP_034454969.1 lysozyme -
KAE70_RS06635 (KAE70_06415) 1562730..1562954 + 225 WP_019224016.1 antitoxin MazE family protein Antitoxin
KAE70_RS06640 (KAE70_06420) 1562954..1563277 + 324 WP_082251260.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KAE70_RS06645 (KAE70_06425) 1563323..1563478 + 156 Protein_1295 putative addiction module antidote protein -
KAE70_RS06650 (KAE70_06430) 1563528..1563806 - 279 WP_082251242.1 hypothetical protein -
KAE70_RS06655 (KAE70_06435) 1563803..1564531 - 729 WP_082251243.1 antA/AntB antirepressor family protein -
KAE70_RS06660 (KAE70_06440) 1564833..1565348 - 516 Protein_1298 Rha family transcriptional regulator -
KAE70_RS06665 (KAE70_06445) 1565659..1566966 - 1308 WP_082251245.1 contractile injection system protein, VgrG/Pvc8 family -
KAE70_RS06670 (KAE70_06450) 1566963..1567187 - 225 WP_011180247.1 tail protein X -
KAE70_RS06675 (KAE70_06455) 1567184..1567564 - 381 WP_011180248.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1551933..1622033 70100


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-102)

Antitoxin

Antitoxin MazE-like

(7-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11627.86 Da        Isoelectric Point: 10.3981

>T199098 WP_082251260.1 NZ_CP072897:1562954-1563277 [Bartonella henselae]
MRGSLVTIAMQGDFGKPRPALIIQANQFSEHTSVTVLPITSTLVAAPLLRITIQPNAKNGLQKPSQVMIDKIMTVRCEKV
SPAFGSIHADKMVEIERCLAVFLGIVK

Download         Length: 324 bp

>T199098 NZ_CP097181:c4232725-4232552 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8776.13 Da        Isoelectric Point: 8.5634

>AT199098 WP_019224016.1 NZ_CP072897:1562730-1562954 [Bartonella henselae]
MATMHVNERVQKHRNAQRKAGLRLMQIWVPDTRQPNFAEECRRQCRLVAKMDKTDTSMQLLMDQSLMDVDGWTE

Download         Length: 225 bp

>AT199098 NZ_CP097181:c4233049-4232753 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References