Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-pasA/PRK09812-HTH
Location 176571..177238 Replicon chromosome
Accession NZ_CP072897
Organism Bartonella henselae strain FR96/BK3

Toxin (Protein)


Gene name pemK Uniprot ID X5M710
Locus tag KAE70_RS00935 Protein ID WP_011180620.1
Coordinates 176571..176903 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID N6VJG4
Locus tag KAE70_RS00940 Protein ID WP_007346764.1
Coordinates 177011..177238 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE70_RS00890 (KAE70_00865) 171689..172168 + 480 Protein_175 hypothetical protein -
KAE70_RS00895 (KAE70_00870) 172158..173408 + 1251 WP_082251037.1 DUF1376 domain-containing protein -
KAE70_RS00900 (KAE70_00875) 173392..173778 + 387 WP_082246570.1 hypothetical protein -
KAE70_RS00905 173960..174280 + 321 Protein_178 hypothetical protein -
KAE70_RS00910 (KAE70_00885) 174468..174740 - 273 WP_082251050.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
KAE70_RS00915 (KAE70_00890) 174737..175027 - 291 WP_082251051.1 hypothetical protein -
KAE70_RS00920 (KAE70_00895) 175239..175685 + 447 WP_082251052.1 single-stranded DNA-binding protein -
KAE70_RS00925 (KAE70_00900) 175739..176233 + 495 WP_038487773.1 hypothetical protein -
KAE70_RS00930 (KAE70_00905) 176314..176571 + 258 WP_034448603.1 antitoxin -
KAE70_RS00935 (KAE70_00910) 176571..176903 + 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KAE70_RS00940 (KAE70_00915) 177011..177238 + 228 WP_007346764.1 DUF6290 family protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11865.88 Da        Isoelectric Point: 10.5590

>T199096 WP_011180620.1 NZ_CP072897:176571-176903 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT

Download         Length: 333 bp

>T199096 NZ_CP097181:c3710463-3710065 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8742.78 Da        Isoelectric Point: 4.8780

>AT199096 WP_007346764.1 NZ_CP072897:177011-177238 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Download         Length: 228 bp

>AT199096 NZ_CP097181:c3710759-3710466 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067W4K9

Antitoxin

Source ID Structure
AlphaFold DB N6VJG4

References