Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE-RHH
Location 174468..175027 Replicon chromosome
Accession NZ_CP072897
Organism Bartonella henselae strain FR96/BK3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KAE70_RS00910 Protein ID WP_082251050.1
Coordinates 174468..174740 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag KAE70_RS00915 Protein ID WP_082251051.1
Coordinates 174737..175027 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE70_RS00865 (KAE70_00840) 169579..169770 - 192 WP_236095467.1 hypothetical protein -
KAE70_RS00870 (KAE70_00845) 170067..170270 - 204 WP_082251039.1 hypothetical protein -
KAE70_RS00875 (KAE70_00850) 170480..170779 - 300 WP_034455006.1 helix-turn-helix transcriptional regulator -
KAE70_RS00880 (KAE70_00855) 170872..171186 + 315 WP_034455005.1 helix-turn-helix transcriptional regulator -
KAE70_RS00885 (KAE70_00860) 171204..171551 + 348 WP_236095468.1 hypothetical protein -
KAE70_RS00890 (KAE70_00865) 171689..172168 + 480 Protein_175 hypothetical protein -
KAE70_RS00895 (KAE70_00870) 172158..173408 + 1251 WP_082251037.1 DUF1376 domain-containing protein -
KAE70_RS00900 (KAE70_00875) 173392..173778 + 387 WP_082246570.1 hypothetical protein -
KAE70_RS00905 173960..174280 + 321 Protein_178 hypothetical protein -
KAE70_RS00910 (KAE70_00885) 174468..174740 - 273 WP_082251050.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
KAE70_RS00915 (KAE70_00890) 174737..175027 - 291 WP_082251051.1 hypothetical protein Antitoxin
KAE70_RS00920 (KAE70_00895) 175239..175685 + 447 WP_082251052.1 single-stranded DNA-binding protein -
KAE70_RS00925 (KAE70_00900) 175739..176233 + 495 WP_038487773.1 hypothetical protein -
KAE70_RS00930 (KAE70_00905) 176314..176571 + 258 WP_034448603.1 antitoxin -
KAE70_RS00935 (KAE70_00910) 176571..176903 + 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin -
KAE70_RS00940 (KAE70_00915) 177011..177238 + 228 WP_007346764.1 DUF6290 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 111262..176233 64971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10775.76 Da        Isoelectric Point: 11.5465

>T199094 WP_082251050.1 NZ_CP072897:c174740-174468 [Bartonella henselae]
MKLVWTRIAHYDRQRIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP

Download         Length: 273 bp

>T199094 NZ_CP097181:2697582-2697689 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11141.51 Da        Isoelectric Point: 4.5837

>AT199094 WP_082251051.1 NZ_CP072897:c175027-174737 [Bartonella henselae]
MAETTFTFRVDDILKSEFSQAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS

Download         Length: 291 bp

>AT199094 NZ_CP097181:c2697535-2697469 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References