Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 149921..150495 Replicon chromosome
Accession NZ_CP072897
Organism Bartonella henselae strain FR96/BK3

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KAE70_RS00695 Protein ID WP_082250871.1
Coordinates 150205..150495 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag KAE70_RS00690 Protein ID WP_082250870.1
Coordinates 149921..150205 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE70_RS00650 (KAE70_00630) 145352..145817 - 466 Protein_127 transcriptional regulator -
KAE70_RS00655 (KAE70_00635) 146015..146306 + 292 Protein_128 helix-turn-helix domain-containing protein -
KAE70_RS00660 (KAE70_00640) 146532..146909 + 378 WP_236095521.1 hypothetical protein -
KAE70_RS00665 (KAE70_00645) 146863..147745 + 883 Protein_130 ParB/RepB/Spo0J family partition protein -
KAE70_RS00670 148066..148331 + 266 Protein_131 DUF5664 domain-containing protein -
KAE70_RS00675 (KAE70_00650) 148318..148605 + 288 WP_082250868.1 hypothetical protein -
KAE70_RS00680 148849..149322 + 474 Protein_133 hypothetical protein -
KAE70_RS00685 (KAE70_00665) 149684..149884 + 201 WP_082250869.1 hypothetical protein -
KAE70_RS00690 (KAE70_00670) 149921..150205 - 285 WP_082250870.1 putative addiction module antidote protein Antitoxin
KAE70_RS00695 (KAE70_00675) 150205..150495 - 291 WP_082250871.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KAE70_RS00700 150811..151200 + 390 WP_236095461.1 hypothetical protein -
KAE70_RS00705 (KAE70_00685) 151264..152161 + 898 Protein_138 hypothetical protein -
KAE70_RS00710 (KAE70_00690) 152367..153525 + 1159 Protein_139 integrase arm-type DNA-binding domain-containing protein -
KAE70_RS00715 (KAE70_00695) 153796..154632 + 837 WP_236095462.1 antA/AntB antirepressor family protein -
KAE70_RS00720 (KAE70_00700) 154649..155197 + 549 WP_082250872.1 antA/AntB antirepressor family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 111262..176233 64971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(9-93)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11255.19 Da        Isoelectric Point: 10.3362

>T199093 WP_082250871.1 NZ_CP072897:c150495-150205 [Bartonella henselae]
MVIIRKTREFDTWLKKLKDKSVKTIILQRVARLRQGLLGDVKFFNNIGELRIHYGAGYRIHFTQEGSEFILLLCGGDKST
QKKDIEQALKLKEEYQ

Download         Length: 291 bp

>T199093 NZ_CP097181:2697047-2697154 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10283.68 Da        Isoelectric Point: 5.8085

>AT199093 WP_082250870.1 NZ_CP072897:c150205-149921 [Bartonella henselae]
MKATLFKPEEYLETPEEQQMFLNEAFKTGDAAHIADAIGIVARAQNMSALARTTDRERSGLYRSLSKDGNPKLSTLVAVL
SALNLQLNVQSSIS

Download         Length: 285 bp

>AT199093 NZ_CP097181:c2697000-2696934 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References