Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 123613..124093 | Replicon | chromosome |
| Accession | NZ_CP072897 | ||
| Organism | Bartonella henselae strain FR96/BK3 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | A0A067WDE7 |
| Locus tag | KAE70_RS00530 | Protein ID | WP_011180622.1 |
| Coordinates | 123824..124093 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | N6VJG4 |
| Locus tag | KAE70_RS00525 | Protein ID | WP_007346764.1 |
| Coordinates | 123613..123840 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE70_RS00470 (KAE70_00465) | 118976..119311 | + | 336 | WP_082250410.1 | hypothetical protein | - |
| KAE70_RS00475 | 119355..119870 | + | 516 | Protein_93 | hypothetical protein | - |
| KAE70_RS00480 (KAE70_00470) | 119988..120416 | - | 429 | WP_082250673.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| KAE70_RS00485 (KAE70_00475) | 120490..120795 | - | 306 | WP_082250408.1 | BrnA antitoxin family protein | - |
| KAE70_RS00490 (KAE70_00480) | 120773..121072 | - | 300 | WP_034448610.1 | BrnT family toxin | - |
| KAE70_RS00495 (KAE70_00485) | 121166..121489 | - | 324 | WP_082250693.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| KAE70_RS00500 (KAE70_00490) | 121489..121713 | - | 225 | WP_038487033.1 | antitoxin MazE family protein | - |
| KAE70_RS00505 (KAE70_00495) | 121836..122267 | + | 432 | WP_082250672.1 | single-stranded DNA-binding protein | - |
| KAE70_RS00510 (KAE70_00500) | 122323..122835 | + | 513 | WP_172642310.1 | hypothetical protein | - |
| KAE70_RS00515 (KAE70_00505) | 122916..123173 | + | 258 | WP_034448603.1 | antitoxin | - |
| KAE70_RS00520 (KAE70_00510) | 123173..123505 | + | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| KAE70_RS00525 (KAE70_00515) | 123613..123840 | + | 228 | WP_007346764.1 | DUF6290 family protein | Antitoxin |
| KAE70_RS00530 (KAE70_00520) | 123824..124093 | + | 270 | WP_011180622.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KAE70_RS00535 | 124123..124515 | - | 393 | WP_223396448.1 | hypothetical protein | - |
| KAE70_RS00540 (KAE70_00525) | 124850..125176 | + | 327 | WP_011180626.1 | hypothetical protein | - |
| KAE70_RS00545 (KAE70_00530) | 125157..126482 | + | 1326 | WP_082250858.1 | phage terminase large subunit | - |
| KAE70_RS00550 (KAE70_00535) | 126467..128521 | + | 2055 | WP_011180822.1 | portal protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 111262..176233 | 64971 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10495.44 Da Isoelectric Point: 10.2009
>T199092 WP_011180622.1 NZ_CP072897:123824-124093 [Bartonella henselae]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAV
GHRKNIYKG
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAV
GHRKNIYKG
Download Length: 270 bp
>T199092 NZ_CP097181:c2483415-2483239 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8742.78 Da Isoelectric Point: 4.8780
>AT199092 WP_007346764.1 NZ_CP072897:123613-123840 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
Download Length: 228 bp
>AT199092 NZ_CP097181:c2483193-2482777 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067WDE7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | N6VJG4 |