Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 1786395..1786914 Replicon chromosome
Accession NZ_CP072891
Organism Enterococcus hirae strain F104

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag J9538_RS08250 Protein ID WP_000588503.1
Coordinates 1786395..1786652 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag J9538_RS08255 Protein ID WP_000388479.1
Coordinates 1786645..1786914 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9538_RS08220 (J9538_08220) 1782486..1783070 - 585 WP_002299575.1 recombinase family protein -
J9538_RS08225 (J9538_08225) 1783281..1783484 - 204 WP_002299573.1 hypothetical protein -
J9538_RS08230 (J9538_08230) 1783494..1783916 - 423 WP_002303116.1 hypothetical protein -
J9538_RS08235 (J9538_08235) 1784154..1784768 + 615 WP_001261742.1 recombinase family protein -
J9538_RS08240 (J9538_08240) 1784933..1785757 - 825 WP_001809248.1 hypothetical protein -
J9538_RS08245 (J9538_08245) 1785781..1785936 - 156 WP_002347142.1 hypothetical protein -
J9538_RS08250 (J9538_08250) 1786395..1786652 - 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
J9538_RS08255 (J9538_08255) 1786645..1786914 - 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J9538_RS08260 (J9538_08260) 1787045..1787224 - 180 WP_001120991.1 hypothetical protein -
J9538_RS13625 1787240..1787440 - 201 WP_002347143.1 hypothetical protein -
J9538_RS08265 (J9538_08265) 1787605..1788312 - 708 WP_002303117.1 hypothetical protein -
J9538_RS08270 (J9538_08270) 1788305..1788742 - 438 WP_002300851.1 hypothetical protein -
J9538_RS08275 (J9538_08275) 1788757..1789008 - 252 WP_002296238.1 hypothetical protein -
J9538_RS08280 (J9538_08280) 1789008..1789214 - 207 WP_002347218.1 hypothetical protein -
J9538_RS08285 (J9538_08285) 1789651..1789911 - 261 WP_002295623.1 hypothetical protein -
J9538_RS13630 1790085..1790189 + 105 WP_008274030.1 putative holin-like toxin -
J9538_RS08295 (J9538_08295) 1790330..1790815 - 486 WP_142654896.1 single-stranded DNA-binding protein -
J9538_RS08300 (J9538_08300) 1790818..1791717 - 900 WP_002303312.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T199085 WP_000588503.1 NZ_CP072891:c1786652-1786395 [Enterococcus hirae]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T199085 NZ_CP097181:672368-672682 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT199085 WP_000388479.1 NZ_CP072891:c1786914-1786645 [Enterococcus hirae]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT199085 NZ_CP097181:672679-673095 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References