Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 40311..40928 Replicon plasmid pF179_1
Accession NZ_CP072885
Organism Enterococcus faecium strain F179

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J9540_RS12680 Protein ID WP_231410992.1
Coordinates 40311..40463 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J9540_RS12685 Protein ID WP_047937794.1
Coordinates 40497..40928 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9540_RS12640 (J9540_12640) 35729..36544 + 816 WP_231410993.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
J9540_RS12645 (J9540_12645) 36547..37032 + 486 WP_002344870.1 single-stranded DNA-binding protein -
J9540_RS12650 (J9540_12650) 37398..37658 + 261 WP_002293538.1 hypothetical protein -
J9540_RS12655 (J9540_12655) 38103..38309 + 207 WP_002325537.1 hypothetical protein -
J9540_RS12660 (J9540_12660) 38309..38560 + 252 WP_212481448.1 hypothetical protein -
J9540_RS12665 (J9540_12665) 38576..39013 + 438 WP_047927652.1 hypothetical protein -
J9540_RS12670 (J9540_12670) 39006..39713 + 708 WP_212481450.1 hypothetical protein -
J9540_RS12675 (J9540_12675) 40007..40186 + 180 WP_002295613.1 hypothetical protein -
J9540_RS12680 (J9540_12680) 40311..40463 + 153 WP_231410992.1 type II toxin-antitoxin system HicA family toxin Toxin
J9540_RS12685 (J9540_12685) 40497..40928 + 432 WP_047937794.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J9540_RS12690 (J9540_12690) 41159..42118 - 960 WP_212481452.1 IS30 family transposase -
J9540_RS14005 42228..43055 + 828 Protein_46 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..174746 174746
- flank IS/Tn - - 41159..42118 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(2-49)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(10-104)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5727.53 Da        Isoelectric Point: 10.2749

>T199078 WP_231410992.1 NZ_CP072885:40311-40463 [Enterococcus faecium]
IEKNGWVERRQEGSHHHLYKDGVRITVPVHANQDLGRGLEKKILKDAGLK

Download         Length: 153 bp

>T199078 NZ_CP097170:c4427567-4427394 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15840.92 Da        Isoelectric Point: 4.0728

>AT199078 WP_047937794.1 NZ_CP072885:40497-40928 [Enterococcus faecium]
MLSEPLAKTYPAIFSPEEGGGYFIEFPDVQGAYTGINEDDISYGIAMAQEVLGMVLADYIEHEELLPEPTPINKISVEDD
SFTTLIRVDVAEYLKETELVKKTLTIPQWADKLGKRAGINFSVLLTESIADKADNILRSGRNN

Download         Length: 432 bp

>AT199078 NZ_CP097170:c4427891-4427595 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References