Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 188809..189338 Replicon chromosome
Accession NZ_CP072884
Organism Enterococcus faecium strain F179

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag J9540_RS00935 Protein ID WP_002294198.1
Coordinates 189072..189338 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag J9540_RS00930 Protein ID WP_002294199.1
Coordinates 188809..189072 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9540_RS00920 (J9540_00920) 186184..188007 + 1824 WP_002294202.1 APC family permease -
J9540_RS00925 (J9540_00925) 188149..188334 - 186 WP_002294201.1 hypothetical protein -
J9540_RS13830 188341..188469 + 129 WP_002294200.1 hypothetical protein -
J9540_RS00930 (J9540_00930) 188809..189072 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J9540_RS00935 (J9540_00935) 189072..189338 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
J9540_RS00940 (J9540_00940) 189539..190027 + 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
J9540_RS00945 (J9540_00945) 190090..190257 + 168 WP_002294195.1 hypothetical protein -
J9540_RS00950 (J9540_00950) 190569..191222 - 654 WP_002317081.1 ABC transporter permease -
J9540_RS00955 (J9540_00955) 191237..192154 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
J9540_RS00960 (J9540_00960) 192151..192792 - 642 WP_002293405.1 ABC transporter permease -
J9540_RS00965 (J9540_00965) 192796..193971 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T199076 WP_002294198.1 NZ_CP072884:189072-189338 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T199076 NZ_CP097170:c4311741-4311451 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACTGGGATATCGCCTGGTCTATTCCGTCAATGATAAAGAGTTACTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAAAACTCAGCCGTTTATGAAGACGCGACAAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT199076 WP_002294199.1 NZ_CP072884:188809-189072 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT199076 NZ_CP097170:c4311973-4311731 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATTACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References