Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
| Location | 167939..169076 | Replicon | plasmid pF39_1 |
| Accession | NZ_CP072882 | ||
| Organism | Enterococcus faecium strain F39 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | J9541_RS12595 | Protein ID | WP_002333003.1 |
| Coordinates | 167939..168802 (-) | Length | 288 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | B3CKC7 |
| Locus tag | J9541_RS12600 | Protein ID | WP_002333002.1 |
| Coordinates | 168804..169076 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J9541_RS12570 (J9541_12565) | 163163..163738 | + | 576 | WP_033603447.1 | IS30 family transposase | - |
| J9541_RS12575 (J9541_12570) | 163810..165423 | - | 1614 | WP_002333004.1 | hypothetical protein | - |
| J9541_RS12580 (J9541_12575) | 165447..166328 | - | 882 | WP_002326774.1 | ABC transporter ATP-binding protein | - |
| J9541_RS12585 (J9541_12580) | 166639..167235 | + | 597 | WP_139914063.1 | TetR/AcrR family transcriptional regulator | - |
| J9541_RS12590 (J9541_12585) | 167404..167808 | - | 405 | Protein_168 | DnaJ domain-containing protein | - |
| J9541_RS12595 (J9541_12590) | 167939..168802 | - | 864 | WP_002333003.1 | zeta toxin family protein | Toxin |
| J9541_RS12600 (J9541_12595) | 168804..169076 | - | 273 | WP_002333002.1 | antitoxin | Antitoxin |
| J9541_RS12605 (J9541_12600) | 169094..169309 | - | 216 | WP_001835296.1 | peptide-binding protein | - |
| J9541_RS12610 (J9541_12605) | 169401..170297 | - | 897 | WP_194175303.1 | ParA family protein | - |
| J9541_RS12615 (J9541_12610) | 170400..170660 | - | 261 | Protein_173 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| J9541_RS12620 (J9541_12615) | 170830..171567 | - | 738 | WP_001038796.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| J9541_RS12625 (J9541_12620) | 171692..171775 | - | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| J9541_RS12630 (J9541_12625) | 171898..172065 | - | 168 | Protein_176 | peptide-binding protein | - |
| J9541_RS12635 (J9541_12630) | 172182..172583 | - | 402 | WP_255322583.1 | hypothetical protein | - |
| J9541_RS12640 (J9541_12635) | 172993..173673 | + | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | erm(B) | - | 1..183270 | 183270 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32365.76 Da Isoelectric Point: 6.3643
>T199075 WP_002333003.1 NZ_CP072882:c168802-167939 [Enterococcus faecium]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVVVIDNDTFKQQHPNFDELV
KLYEKDVVKHATPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKTYAMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGI
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVVVIDNDTFKQQHPNFDELV
KLYEKDVVKHATPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKTYAMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGI
Download Length: 864 bp
>T199075 NZ_CP097170:c4217159-4216872 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10721.29 Da Isoelectric Point: 7.1987
>AT199075 WP_002333002.1 NZ_CP072882:c169076-168804 [Enterococcus faecium]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELKAVHEYWRSMNRYS
KQVLNKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELKAVHEYWRSMNRYS
KQVLNKEKVA
Download Length: 273 bp
>AT199075 NZ_CP097170:c4216885-4216583 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCCTCGGTGCGTATTGATTCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCCTCGGTGCGTATTGATTCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|