Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB-HicA |
| Location | 23767..24384 | Replicon | plasmid pF39_1 |
| Accession | NZ_CP072882 | ||
| Organism | Enterococcus faecium strain F39 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | J9541_RS11910 | Protein ID | WP_224451579.1 |
| Coordinates | 23767..23919 (+) | Length | 51 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A3F3LXY4 |
| Locus tag | J9541_RS11915 | Protein ID | WP_002326154.1 |
| Coordinates | 23953..24384 (+) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J9541_RS11865 (J9541_11860) | 19335..19811 | + | 477 | WP_002305045.1 | PTS glucose transporter subunit IIA | - |
| J9541_RS13170 | 20079..20165 | + | 87 | Protein_23 | IS200/IS605 family transposase | - |
| J9541_RS11870 (J9541_11865) | 20160..20363 | + | 204 | Protein_24 | hypothetical protein | - |
| J9541_RS11875 (J9541_11870) | 20522..20666 | - | 145 | Protein_25 | putative holin-like toxin | - |
| J9541_RS11880 (J9541_11875) | 20799..21059 | + | 261 | WP_002326514.1 | hypothetical protein | - |
| J9541_RS11885 (J9541_11880) | 21503..21709 | + | 207 | WP_002305810.1 | hypothetical protein | - |
| J9541_RS11890 (J9541_11885) | 21709..21960 | + | 252 | WP_002343760.1 | hypothetical protein | - |
| J9541_RS11895 (J9541_11890) | 21976..22413 | + | 438 | WP_002343761.1 | hypothetical protein | - |
| J9541_RS11900 (J9541_11895) | 22406..23113 | + | 708 | WP_002322978.1 | hypothetical protein | - |
| J9541_RS11905 (J9541_11900) | 23494..23673 | + | 180 | Protein_31 | hypothetical protein | - |
| J9541_RS11910 (J9541_11905) | 23767..23919 | + | 153 | WP_224451579.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| J9541_RS11915 (J9541_11910) | 23953..24384 | + | 432 | WP_002326154.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| J9541_RS11920 (J9541_11915) | 24565..25713 | - | 1149 | WP_002287525.1 | IS200/IS605 family element RNA-guided endonuclease TnpB | - |
| J9541_RS11925 (J9541_11920) | 25730..26134 | - | 405 | WP_002287522.1 | IS200/IS605-like element ISEfa4 family transposase | - |
| J9541_RS11930 (J9541_11925) | 26318..27295 | - | 978 | WP_002326152.1 | choloylglycine hydrolase | - |
| J9541_RS11935 (J9541_11930) | 27330..28634 | - | 1305 | WP_113813881.1 | conjugated bile salt MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | erm(B) | - | 1..183270 | 183270 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5815.65 Da Isoelectric Point: 10.3560
>T199074 WP_224451579.1 NZ_CP072882:23767-23919 [Enterococcus faecium]
IEKNGWVERRQEGFHHHLYKDGVRITVPVHANQDLGRGLERKILKDAGLK
IEKNGWVERRQEGFHHHLYKDGVRITVPVHANQDLGRGLERKILKDAGLK
Download Length: 153 bp
>T199074 NZ_CP097170:3792175-3792717 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTATTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTAATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTATTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTAATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG
Antitoxin
Download Length: 144 a.a. Molecular weight: 15825.95 Da Isoelectric Point: 4.1638
>AT199074 WP_002326154.1 NZ_CP072882:23953-24384 [Enterococcus faecium]
MLSEPLAKTYPAIFSPEEGGGYFIEFPDVQGAYTGINEDDISYGIAMAQEVLGMVLADYIEHEDLLPEPTPINKITVEDD
SFTTLIRVDVAKYLKDTELVKKTLTIPQWADKLGKRAGINFSVLLTESIADKADNILRSGRNN
MLSEPLAKTYPAIFSPEEGGGYFIEFPDVQGAYTGINEDDISYGIAMAQEVLGMVLADYIEHEDLLPEPTPINKITVEDD
SFTTLIRVDVAKYLKDTELVKKTLTIPQWADKLGKRAGINFSVLLTESIADKADNILRSGRNN
Download Length: 432 bp
>AT199074 NZ_CP097170:3791880-3792191 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|