Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 198454..198983 Replicon chromosome
Accession NZ_CP072881
Organism Enterococcus faecium strain F39

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag J9541_RS00980 Protein ID WP_002294198.1
Coordinates 198717..198983 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag J9541_RS00975 Protein ID WP_002294199.1
Coordinates 198454..198717 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9541_RS00960 (J9541_00960) 194864..196309 + 1446 WP_002337067.1 alpha-N-arabinofuranosidase -
J9541_RS00965 (J9541_00965) 196314..196580 + 267 WP_002315578.1 DUF6171 family protein -
J9541_RS00970 (J9541_00970) 196633..197823 + 1191 WP_002298336.1 arabinan endo-1,5-alpha-L-arabinosidase -
J9541_RS00975 (J9541_00975) 198454..198717 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J9541_RS00980 (J9541_00980) 198717..198983 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
J9541_RS00985 (J9541_00985) 199184..199672 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
J9541_RS00990 (J9541_00990) 200214..200867 - 654 WP_002317081.1 ABC transporter permease -
J9541_RS00995 (J9541_00995) 200882..201799 - 918 WP_002298332.1 osmoprotectant ABC transporter substrate-binding protein -
J9541_RS01000 (J9541_01000) 201796..202437 - 642 WP_002293405.1 ABC transporter permease -
J9541_RS01005 (J9541_01005) 202441..203616 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T199072 WP_002294198.1 NZ_CP072881:198717-198983 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T199072 NZ_CP097170:c3730392-3730090 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCCGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT199072 WP_002294199.1 NZ_CP072881:198454-198717 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT199072 NZ_CP097170:c3730054-3729713 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References