Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2347370..2347963 Replicon chromosome
Accession NZ_CP072873
Organism Pseudomonas fluorescens strain JNU01

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J9321_RS10435 Protein ID WP_120447526.1
Coordinates 2347370..2347672 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J9321_RS10440 Protein ID WP_120447525.1
Coordinates 2347676..2347963 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9321_RS10410 (J9321_10410) 2343480..2344202 + 723 WP_120447529.1 cobalt-precorrin-6A reductase -
J9321_RS10415 (J9321_10415) 2344333..2344611 + 279 WP_120447528.1 hypothetical protein -
J9321_RS10420 (J9321_10420) 2344608..2345096 + 489 WP_120447527.1 PIN domain-containing protein -
J9321_RS10425 (J9321_10425) 2345304..2346140 - 837 WP_240435264.1 IS3 family transposase -
J9321_RS30355 2346137..2346439 - 303 WP_065899480.1 IS3 family transposase -
J9321_RS10430 (J9321_10430) 2346599..2346850 - 252 WP_065900255.1 DUF6124 family protein -
J9321_RS10435 (J9321_10435) 2347370..2347672 + 303 WP_120447526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9321_RS10440 (J9321_10440) 2347676..2347963 + 288 WP_120447525.1 putative addiction module antidote protein Antitoxin
J9321_RS10445 (J9321_10445) 2348059..2348454 + 396 WP_065900253.1 DUF2946 domain-containing protein -
J9321_RS10450 (J9321_10450) 2348502..2348984 + 483 WP_120447524.1 copper chaperone PCu(A)C -
J9321_RS10455 (J9321_10455) 2348996..2349397 + 402 WP_162946059.1 DUF2946 domain-containing protein -
J9321_RS10460 (J9321_10460) 2349491..2351551 + 2061 WP_065900248.1 TonB-dependent copper receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-91)

Antitoxin

Uncharacterized protein HI1420

(4-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11659.38 Da        Isoelectric Point: 9.9393

>T199067 WP_120447526.1 NZ_CP072873:2347370-2347672 [Pseudomonas fluorescens]
MIQFKKSKYFLEWLDSLRSKPARARVLARLDNAQWGNFGDCEALGNGVLEMRIHYGPGYRVYFTRRGEVVYLLLIGGDKS
TQKRDIQRAKQIAEDFEKTE

Download         Length: 303 bp

>T199067 NZ_CP097170:c2267346-2267239 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10294.71 Da        Isoelectric Point: 4.4791

>AT199067 WP_120447525.1 NZ_CP072873:2347676-2347963 [Pseudomonas fluorescens]
MSEFTDFDVAEHLKTPEDMAEYLEACFEEDAGDGLLIRSALNNIARAQGMTQVARDAGLGRESLYKALSSTGNPEFATIM
KVMKALGLKLHATAV

Download         Length: 288 bp

>AT199067 NZ_CP097170:2267399-2267460 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References