Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 47292..47947 Replicon plasmid p4
Accession NZ_CP072869
Organism Rhizobium sp. NLR16a

Toxin (Protein)


Gene name vapC Uniprot ID A0A432N9U1
Locus tag J7U39_RS27230 Protein ID WP_018496488.1
Coordinates 47292..47711 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag J7U39_RS27235 Protein ID WP_127431704.1
Coordinates 47711..47947 (-) Length 79 a.a.

Genomic Context

J7U39_RS27215J7U39_RS27225J7U39_RS27240J7U39_RS27245J7U39_RS27250J7U39_RS31955J7U39_RS27210J7U39_RS31965J7U39_RS27230J7U39_RS27235J7U39_RS27255J7U39_RS31970
Location: 45635..45912 (278 bp)
Type: Others
Protein ID: Protein_41
Location: 46818..47143 (326 bp)
Type: Others
Protein ID: Protein_43
Location: 49039..49509 (471 bp)
Type: Others
Protein ID: WP_210633164.1
Location: 49787..50482 (696 bp)
Type: Others
Protein ID: WP_210633165.1
Location: 50723..50965 (243 bp)
Type: Others
Protein ID: WP_210633166.1
Location: 43550..43846 (297 bp)
Type: Others
Protein ID: WP_247241811.1
Location: 44097..45362 (1266 bp)
Type: Others
Protein ID: WP_210633163.1
Location: 46325..46793 (469 bp)
Type: Others
Protein ID: Protein_42
Location: 47292..47711 (420 bp)
Type: Toxin
Protein ID: WP_018496488.1
Location: 47711..47947 (237 bp)
Type: Antitoxin
Protein ID: WP_127431704.1
Location: 50980..51099 (120 bp)
Type: Others
Protein ID: Protein_49
Location: 51179..51323 (145 bp)
Type: Others
Protein ID: Protein_50
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J7U39_RS3195543550..43846-297WP_247241811.1iron-containing alcohol dehydrogenase-
J7U39_RS27210 (J7U39_27210)44097..45362-1266WP_210633163.1plasmid partitioning protein RepA-
J7U39_RS27215 (J7U39_27215)45635..45912+278Protein_41substrate-binding domain-containing protein-
J7U39_RS3196546325..46793-469Protein_42ABC transporter permease subunit-
J7U39_RS27225 (J7U39_27225)46818..47143+326Protein_43DDE-type integrase/transposase/recombinase-
J7U39_RS27230 (J7U39_27230)47292..47711-420WP_018496488.1type II toxin-antitoxin system VapC family toxinToxin
J7U39_RS27235 (J7U39_27235)47711..47947-237WP_127431704.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
J7U39_RS27240 (J7U39_27240)49039..49509+471WP_210633164.1TlpA disulfide reductase family protein-
J7U39_RS27245 (J7U39_27245)49787..50482+696WP_210633165.1response regulator transcription factor-
J7U39_RS27250 (J7U39_27250)50723..50965+243WP_210633166.1hypothetical protein-
J7U39_RS27255 (J7U39_27255)50980..51099-120Protein_49transposase-
J7U39_RS3197051179..51323-145Protein_50transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmid--1..404135404135
-flankIS/Tn--50977..51099122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-117)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15616.86 Da        Isoelectric Point: 4.9496

>T199060 WP_018496488.1 NZ_CP072869:c47711-47292 [Rhizobium sp. NLR16a]
MARYMLDTNMCIYLMKNQPEQVARRFASCYVGDVVMSAITFAELEYGVSASDDPARELDNLTALAELITVEPFGIAAARA
YGPVRMATRDRKKDHLDKLIASHAIALDTVLVTNNTRDFLAYPGLKLENWLDAERRETN

Download         Length: 420 bp

>T199060 NZ_CP097170:802877-803173 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9065.18 Da        Isoelectric Point: 5.6514

>AT199060 WP_127431704.1 NZ_CP072869:c47947-47711 [Rhizobium sp. NLR16a]
MHTTKAFKNGNSQAVRIPAELAFERTDVELEIERIGDELRIRPVHRSLAGVLDVFARFSPDFMRDGRESHEQEERDKI

Download         Length: 237 bp

>AT199060 NZ_CP097170:803175-803570 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A432N9U1

Antitoxin

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Source
ID
Structure
No matching records found

References