Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 154898..155565 Replicon plasmid p1
Accession NZ_CP072866
Organism Rhizobium sp. NLR16a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J7U39_RS20480 Protein ID WP_210632081.1
Coordinates 155155..155565 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J7U39_RS20475 Protein ID WP_210632185.1
Coordinates 154898..155158 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7U39_RS32190 150015..150143 - 129 WP_259665272.1 hypothetical protein -
J7U39_RS20440 (J7U39_20440) 150823..151065 + 243 WP_210632076.1 BON domain-containing protein -
J7U39_RS20450 (J7U39_20450) 151498..151701 + 204 Protein_154 hypothetical protein -
J7U39_RS20455 (J7U39_20455) 151698..152588 - 891 WP_210632077.1 LysR substrate-binding domain-containing protein -
J7U39_RS20460 (J7U39_20460) 152694..153398 + 705 WP_210632078.1 SDR family oxidoreductase -
J7U39_RS20465 (J7U39_20465) 153412..153987 + 576 WP_210632079.1 pyridoxamine 5'-phosphate oxidase family protein -
J7U39_RS20470 (J7U39_20470) 154265..154822 + 558 WP_210632080.1 DUF3299 domain-containing protein -
J7U39_RS20475 (J7U39_20475) 154898..155158 + 261 WP_210632185.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J7U39_RS20480 (J7U39_20480) 155155..155565 + 411 WP_210632081.1 type II toxin-antitoxin system VapC family toxin Toxin
J7U39_RS20485 (J7U39_20485) 155683..157866 - 2184 WP_210632082.1 catalase/peroxidase HPI -
J7U39_RS20490 (J7U39_20490) 158013..158927 + 915 WP_210632083.1 hydrogen peroxide-inducible genes activator -
J7U39_RS20495 (J7U39_20495) 158973..159794 - 822 WP_210632084.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..546133 546133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(8-45)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14846.09 Da        Isoelectric Point: 4.9208

>T199058 WP_210632081.1 NZ_CP072866:155155-155565 [Rhizobium sp. NLR16a]
VITHLIDTNAVIALIGRKSDMLLSRVMESDEGSIGLSTVVMHELYYGAYKSAKISYNLETLRLFMADFPAVGFEREDALA
AGEIRAALAAKGKPIGPYDVLIAAQARSRDLVLVTNNVGEFQRVEGLCVEDWTVGR

Download         Length: 411 bp

>T199058 NZ_CP097170:363557-363832 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9934.12 Da        Isoelectric Point: 5.1486

>AT199058 WP_210632185.1 NZ_CP072866:154898-155158 [Rhizobium sp. NLR16a]
MPQYARVFQSGNSQAVRLPKEFRFDVEQVEVTREGDAVILRPRVDSRVQWASLRNALERGLSDDFMAQGREQPEDQERPG
LQGLFK

Download         Length: 261 bp

>AT199058 NZ_CP097170:363829-364188 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References