Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2270072..2270666 Replicon chromosome
Accession NZ_CP072865
Organism Rhizobium sp. NLR16a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J7U39_RS11180 Protein ID WP_210628261.1
Coordinates 2270277..2270666 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J7U39_RS11175 Protein ID WP_210631647.1
Coordinates 2270072..2270293 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7U39_RS11165 (J7U39_11165) 2265179..2266438 - 1260 WP_210628259.1 N-acetylmuramoyl-L-alanine amidase -
J7U39_RS11170 (J7U39_11170) 2267061..2269928 + 2868 WP_210628260.1 ribonuclease E/G -
J7U39_RS11175 (J7U39_11175) 2270072..2270293 + 222 WP_210631647.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J7U39_RS11180 (J7U39_11180) 2270277..2270666 + 390 WP_210628261.1 PIN domain nuclease Toxin
J7U39_RS11185 (J7U39_11185) 2270679..2272337 - 1659 WP_210628262.1 acyl-CoA dehydrogenase family protein -
J7U39_RS11190 (J7U39_11190) 2272516..2273472 + 957 WP_064801874.1 aspartate carbamoyltransferase catalytic subunit -
J7U39_RS11195 (J7U39_11195) 2273469..2274758 + 1290 WP_210628263.1 dihydroorotase -
J7U39_RS11200 (J7U39_11200) 2274801..2275421 + 621 WP_210628264.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14675.95 Da        Isoelectric Point: 6.3306

>T199056 WP_210628261.1 NZ_CP072865:2270277-2270666 [Rhizobium sp. NLR16a]
VIVVDSSVWIAHLRGMENAARRRLQNIEDPLEILVGDLILMEVLQGARNDRHATTIEANLRQFTIRPMLDDSLAVRAARN
YRLLRERGITVRKIIDVIIGTFCIQEGHSLLHDDSDFDPMAEHLGLRIA

Download         Length: 390 bp

>T199056 NZ_CP097170:278796-278903 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8163.22 Da        Isoelectric Point: 10.4368

>AT199056 WP_210631647.1 NZ_CP072865:2270072-2270293 [Rhizobium sp. NLR16a]
MRTNIDIDDALLAAAMTATGLATKKATIEQALRSLVDRHRRKNAIANLSGIGWEGDLEGMRRDRPDETSDRRR

Download         Length: 222 bp

>AT199056 NZ_CP097170:c278747-278684 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References