Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4184825..4185420 Replicon chromosome
Accession NZ_CP072858
Organism Escherichia coli strain 184/2aE

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag J9158_RS20215 Protein ID WP_000239579.1
Coordinates 4184825..4185175 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag J9158_RS20220 Protein ID WP_001223208.1
Coordinates 4185169..4185420 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9158_RS20195 (4180271) 4180271..4181293 - 1023 WP_001295197.1 ABC transporter permease -
J9158_RS20200 (4181307) 4181307..4182809 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
J9158_RS20205 (4182949) 4182949..4183905 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
J9158_RS20210 (4184215) 4184215..4184745 + 531 WP_000055072.1 inorganic diphosphatase -
J9158_RS20215 (4184825) 4184825..4185175 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
J9158_RS20220 (4185169) 4185169..4185420 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
J9158_RS20225 (4185632) 4185632..4185973 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
J9158_RS20230 (4185976) 4185976..4189755 - 3780 WP_086669469.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T199048 WP_000239579.1 NZ_CP072858:c4185175-4184825 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T199048 NZ_CP097128:c3008292-3007906 [Conexibacter sp. DBS9H8]
ATGATCGCGGTGGACTCCTCGGCCCTCATCGCCGTTGTGCTCGGCGAGGCTGATGCGGAGCGTTTTCTTGCCGCCATGGG
AGCGGACGCCGCCTCACTGTCCGCGGTGTCGTTGACCGAAGCCACCATCGTGGCCGAGGCCCGCCAGGGTGCGGACGCGG
TGCGCGACCTCGAACTGCTGGTGGCGGGCGTGATCGATCGGGTCGTTGCCGTCGACGCAACACACGCGCGAGCCGCCGCC
GCGGCCTGGCGGCGCTTTGGCAAGGGCCGCCATCCGGCGGGACTGAACCTGGGTGACTGCTTTGCCTACGCGACGGCATC
GCTGGCCGGCGCACCGCTGCTCTTCAAGGGCAACGACTTTGCGCAGACCGATCTACCTGCTGCGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT199048 WP_001223208.1 NZ_CP072858:c4185420-4185169 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT199048 NZ_CP097128:c3008537-3008289 [Conexibacter sp. DBS9H8]
GTGGCGCTCAACATCAAGGATCCTGAGACCGACCGTCTCGCCCGTGAACTCGCCGACCTCTCCGGCCAGTCGATCACGAC
GGCGGTGCGGGAGGCCCTCGAGGAACGGATTGCCGTCCTCACCGCTCGCGCCCGTGCGTCTGGCCCCGGGCTCGATGGGA
TCATCAGCCGGGGTCGGGCACGGAGCATCCTCGACGACCGTTCCCCTGAGGAGATCCTCGGCTACGGTGCCGATGGTCTG
CCGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References