199015

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 2813327..2813903 Replicon chromosome
Accession NZ_CP072853
Organism Leptospira interrogans strain UI29382

Toxin (Protein)


Gene name chpK Uniprot ID Q93MT8
Locus tag J9305_RS11590 Protein ID WP_000617906.1
Coordinates 2813327..2813668 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID Q93MT9
Locus tag J9305_RS11595 Protein ID WP_000844758.1
Coordinates 2813655..2813903 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9305_RS11570 (J9305_11515) 2808564..2808968 - 405 WP_001974506.1 pyridoxamine 5'-phosphate oxidase family protein -
J9305_RS11575 (J9305_11520) 2808965..2809432 - 468 WP_000060051.1 hypothetical protein -
J9305_RS11580 (J9305_11525) 2810236..2811171 + 936 WP_000004530.1 ornithine carbamoyltransferase -
J9305_RS11585 (J9305_11530) 2811311..2812303 + 993 WP_000041093.1 aldolase/citrate lyase family protein -
J9305_RS11590 (J9305_11535) 2813327..2813668 - 342 WP_000617906.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J9305_RS11595 (J9305_11540) 2813655..2813903 - 249 WP_000844758.1 ribbon-helix-helix domain-containing protein Antitoxin
J9305_RS11600 (J9305_11545) 2814719..2815015 - 297 WP_000477061.1 helix-turn-helix transcriptional regulator -
J9305_RS11605 (J9305_11550) 2815169..2815627 + 459 WP_025176015.1 hypothetical protein -
J9305_RS11610 (J9305_11555) 2816269..2818251 - 1983 WP_000802799.1 HD family phosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12372.25 Da        Isoelectric Point: 6.3272

>T199015 WP_000617906.1 NZ_CP072853:c2813668-2813327 [Leptospira interrogans]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD

Download         Length: 342 bp

>T199015 NZ_CP097107:6850-7125 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9380.77 Da        Isoelectric Point: 10.3815

>AT199015 WP_000844758.1 NZ_CP072853:c2813903-2813655 [Leptospira interrogans]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT199015 NZ_CP097107:7122-7481 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTGATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTTAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4MS74

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6HD92

References