Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 525059..525695 Replicon chromosome
Accession NZ_CP072851
Organism Bacillus altitudinis strain 6ww6

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag J9319_RS02530 Protein ID WP_003214169.1
Coordinates 525345..525695 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag J9319_RS02525 Protein ID WP_003214273.1
Coordinates 525059..525340 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9319_RS02505 (J9319_02505) 521213..521818 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
J9319_RS02510 (J9319_02510) 521913..522278 + 366 WP_017358398.1 holo-ACP synthase -
J9319_RS02515 (J9319_02515) 522439..523455 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
J9319_RS02520 (J9319_02520) 523584..524765 + 1182 WP_108611670.1 alanine racemase -
J9319_RS02525 (J9319_02525) 525059..525340 + 282 WP_003214273.1 hypothetical protein Antitoxin
J9319_RS02530 (J9319_02530) 525345..525695 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
J9319_RS02535 (J9319_02535) 525810..526640 + 831 WP_007496484.1 RsbT co-antagonist protein RsbRA -
J9319_RS02540 (J9319_02540) 526645..527013 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
J9319_RS02545 (J9319_02545) 527016..527417 + 402 WP_003214085.1 anti-sigma regulatory factor -
J9319_RS02550 (J9319_02550) 527428..528435 + 1008 WP_008346904.1 PP2C family protein-serine/threonine phosphatase -
J9319_RS02555 (J9319_02555) 528495..528824 + 330 WP_007496474.1 anti-sigma factor antagonist -
J9319_RS02560 (J9319_02560) 528821..529309 + 489 WP_210552309.1 anti-sigma B factor RsbW -
J9319_RS02565 (J9319_02565) 529275..530063 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
J9319_RS02570 (J9319_02570) 530063..530662 + 600 WP_017358391.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T199014 WP_003214169.1 NZ_CP072851:525345-525695 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T199014 NZ_CP097105:c45397-45044 [Pseudomonas sp. NY11382]
ATGAGCAAGCGCCCGCAGCATCAATTCGACCGCGGTGACATCGTCTCCCTGGACATGGGTAGCGCTTCAACGCAGGTGGC
CTGTAAAGCGCTCGTGCTTTCCCCAGCAGCGTACAACGCCCTGGGGCTCGCCCTAGCCGTTCCTATCACCGAGCACGACA
GCAGCCGCTACGCCGGCTTTGCCGTCGCGATCGTCCTTCCGGGGCGCACGCCGGCGAGCGGGGCAGCCTTGGTCAACCTG
GTGCGGCCGGTGGATCTTGCTGCAAGAGGTGCGAAGCTGCTCGGGAAGGCACCCCAGACAACCATAGATGAAGCCCTGCA
GCGCCTGCAGGCGGTTGTTGGGAAAGACCAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT199014 WP_003214273.1 NZ_CP072851:525059-525340 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT199014 NZ_CP097105:c45642-45394 [Pseudomonas sp. NY11382]
TTGAAAACGACTATCCGTGCGATTGGGAATTCTCAGGGCATCACGATACCCAAGCCGTTGCTGGCCGAACTCGGCGTAAG
CCTTGGCGACCCTGTAGACGTCTCCTTCAAAGATCAGACCCTGGTGGTGTCCAAGGTCGCTACCGAATACGACCTCAGCA
CGCTAGTCGCCCAGTGTGACCTGGAGGCCCCGGAGCCGCCGGACATCCACTGTTGGAGAACATCCGCGCCGGTAGGAAAC
GAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References