Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4266549..4267114 Replicon chromosome
Accession NZ_CP072846
Organism Brevibacterium oceani strain WW007

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J9314_RS18900 Protein ID WP_210603806.1
Coordinates 4266549..4266920 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J9314_RS18905 Protein ID WP_210603807.1
Coordinates 4266917..4267114 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9314_RS18880 4262086..4263645 - 1560 WP_210603803.1 long-chain fatty acid--CoA ligase -
J9314_RS18885 4263741..4264955 - 1215 WP_246490513.1 DUF5938 domain-containing protein -
J9314_RS18890 4264965..4265756 - 792 WP_210603804.1 SDR family oxidoreductase -
J9314_RS18895 4265878..4266531 + 654 WP_210603805.1 TetR/AcrR family transcriptional regulator -
J9314_RS18900 4266549..4266920 - 372 WP_210603806.1 type II toxin-antitoxin system VapC family toxin Toxin
J9314_RS18905 4266917..4267114 - 198 WP_210603807.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J9314_RS18910 4267270..4268586 - 1317 WP_210603808.1 DUF445 domain-containing protein -
J9314_RS18915 4268905..4269345 + 441 WP_210603809.1 hypothetical protein -
J9314_RS18920 4269396..4270217 + 822 WP_210603810.1 class I SAM-dependent methyltransferase -
J9314_RS18925 4270416..4271591 + 1176 WP_246490514.1 acetylornithine deacetylase -
J9314_RS18930 4271714..4271929 + 216 WP_210603811.1 DUF2945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13856.97 Da        Isoelectric Point: 4.9263

>T198976 WP_210603806.1 NZ_CP072846:c4266920-4266549 [Brevibacterium oceani]
MILVDTSVWIDHLHRPDPLLQRLLEVDEVGCHSAVVEELGLGTLKSRNDFLNDLESLFRFPVLAHDELMSFIAMRSLWGR
GLSAADVHLLGSVLVIDGARLWTRDKRLLRAAEEVGCAFVHDE

Download         Length: 372 bp

>T198976 NZ_CP097079:811500-811910 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7069.04 Da        Isoelectric Point: 6.3085

>AT198976 WP_210603807.1 NZ_CP072846:c4267114-4266917 [Brevibacterium oceani]
MRTTVTIDDELMDKAAEISGITERSALIREALKTLVRVESARRLAALGGSDPESSAALRRRNEVA

Download         Length: 198 bp

>AT198976 NZ_CP097079:811253-811519 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References