Detailed information of TA system TA198973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2965037..2965562
• Replicon: chromosome
• Accession: NZ_CP072844
• Organism: Psychrosphaera aestuarii strain PSC101

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J9318_RS13480
• Protein ID: WP_210560395.1
• Coordinates: 2965037..2965324 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J9318_RS13485
• Protein ID: WP_210560396.1
• Coordinates: 2965314..2965562 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9318_RS13445	2960332..2960727	+	396	WP_210560388.1	hypothetical protein	-
J9318_RS13450	2960848..2961162	+	315	WP_210560389.1	hypothetical protein	-
J9318_RS13455	2961296..2961541	+	246	WP_210560390.1	hypothetical protein	-
J9318_RS13460	2961637..2962113	+	477	WP_210560391.1	hypothetical protein	-
J9318_RS13465	2962193..2962612	+	420	WP_210560392.1	hypothetical protein	-
J9318_RS13470	2962750..2963181	+	432	WP_210560393.1	hypothetical protein	-
J9318_RS13475	2963357..2964004	+	648	WP_210560394.1	hypothetical protein	-
J9318_RS13480	2965037..2965324	-	288	WP_210560395.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J9318_RS13485	2965314..2965562	-	249	WP_210560396.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J9318_RS13490	2965755..2966069	+	315	WP_210560397.1	hypothetical protein	-
J9318_RS13495	2966213..2966524	+	312	WP_210560398.1	hypothetical protein	-
J9318_RS13500	2966536..2966763	+	228	WP_210560399.1	hypothetical protein	-
J9318_RS13505	2966821..2967330	+	510	WP_210560400.1	hypothetical protein	-
J9318_RS13510	2967819..2968304	+	486	WP_210560401.1	cell envelope integrity protein TolA	-
J9318_RS13515	2968461..2968727	+	267	WP_210560402.1	lipoprotein	-
J9318_RS13520	2968933..2969313	+	381	WP_210560403.1	DUF3224 domain-containing protein	-
J9318_RS13525	2969481..2970374	+	894	WP_210560404.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	2957181..2972459	15278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10986.85 Da
• Isoelectric Point: 10.5954

>T198973 WP_210560395.1 NZ_CP072844:c2965324-2965037 [Psychrosphaera aestuarii]
MTYELEFNKSAFKEWKKLGSTVREQFKKKLKAVLDGPHITSAKLTGANNLYKIKLRQAGYRLVYEVQDEKVTVKVITVGK
RDKGEVYKIAQHRIS

Nucleotide

• Length: 288 bp

>T198973 NZ_CP097077:c194051-193569 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9085.39 Da
• Isoelectric Point: 4.3219

>AT198973 WP_210560396.1 NZ_CP072844:c2965562-2965314 [Psychrosphaera aestuarii]
MANRILTETAASISELKANPMKVALSADGEAIAVLNRNEPAFYCIPAATYEQMIDHLEDLELLRIVEQRRGEESIKVGLN
DL

Nucleotide

• Length: 249 bp

>AT198973 NZ_CP097077:c194305-194039 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA