Detailed information of TA system TA198972

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1459168..1459699
• Replicon: chromosome
• Accession: NZ_CP072844
• Organism: Psychrosphaera aestuarii strain PSC101

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J9318_RS06640
• Protein ID: WP_210562252.1
• Coordinates: 1459409..1459699 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: J9318_RS06635
• Protein ID: WP_210562251.1
• Coordinates: 1459168..1459407 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9318_RS06605	1455264..1455530	-	267	WP_210562246.1	hypothetical protein	-
J9318_RS06610	1455565..1456108	-	544	Protein_1282	IS3 family transposase	-
J9318_RS06615	1456182..1456718	-	537	WP_210562247.1	GNAT family protein	-
J9318_RS06620	1456818..1457249	-	432	WP_210562248.1	hypothetical protein	-
J9318_RS06625	1457350..1458483	-	1134	WP_210562249.1	alpha/beta hydrolase-fold protein	-
J9318_RS06630	1458658..1459011	-	354	WP_210562250.1	hypothetical protein	-
J9318_RS06635	1459168..1459407	+	240	WP_210562251.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
J9318_RS06640	1459409..1459699	+	291	WP_210562252.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J9318_RS06645	1459819..1460817	-	999	WP_210562253.1	alpha/beta hydrolase	-
J9318_RS06650	1460975..1461208	-	234	WP_210562254.1	hypothetical protein	-
J9318_RS06655	1461365..1461730	-	366	WP_244731956.1	hypothetical protein	-
J9318_RS06660	1461840..1462163	-	324	WP_210562256.1	hypothetical protein	-
J9318_RS06665	1462243..1462623	-	381	WP_210562257.1	hypothetical protein	-
J9318_RS06670	1464258..1464584	-	327	WP_210562258.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-91)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11470.29 Da
• Isoelectric Point: 9.9502

>T198972 WP_210562252.1 NZ_CP072844:1459409-1459699 [Psychrosphaera aestuarii]
MKFNLSKKAKLDLIKIARYTQLNWGWQQRNDYLKLLDSAFHQIAAEPELGYACDYIREGYRKRPQGSHVIYYKEFGREEV
VIIRVLHKSMDVHRAI

Nucleotide

• Length: 291 bp

>T198972 NZ_CP097077:156523-156966 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8824.69 Da
• Isoelectric Point: 4.2942

>AT198972 WP_210562251.1 NZ_CP072844:1459168-1459407 [Psychrosphaera aestuarii]
MAKNTSVTLGEHFDSFISQQLESGRYGSASEVLRAGLRALEDQELKMNNLRNMLVEGENSGIADYSYDTLLSDLDKENH

Nucleotide

• Length: 240 bp

>AT198972 NZ_CP097077:156296-156526 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA