Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 999531..1000093 Replicon chromosome
Accession NZ_CP072844
Organism Psychrosphaera aestuarii strain PSC101

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag J9318_RS04605 Protein ID WP_210561704.1
Coordinates 999776..1000093 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag J9318_RS04600 Protein ID WP_210561702.1
Coordinates 999531..999776 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9318_RS04585 996327..997082 - 756 WP_210561688.1 cytochrome b/b6 domain-containing protein -
J9318_RS04590 997469..998446 - 978 WP_210561690.1 alpha/beta fold hydrolase -
J9318_RS04595 998484..999350 - 867 WP_210561700.1 alpha/beta fold hydrolase -
J9318_RS04600 999531..999776 + 246 WP_210561702.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
J9318_RS04605 999776..1000093 + 318 WP_210561704.1 CcdB family protein Toxin
J9318_RS04610 1000181..1000570 - 390 WP_210561711.1 hypothetical protein -
J9318_RS04615 1000671..1001459 - 789 WP_210561713.1 trypsin-like serine protease -
J9318_RS04620 1001611..1002501 - 891 WP_210561715.1 putative phage abortive infection protein -
J9318_RS04625 1002656..1003033 - 378 WP_210561717.1 hypothetical protein -
J9318_RS04630 1003163..1003900 - 738 WP_210561719.1 hypothetical protein -
J9318_RS04635 1004067..1004399 - 333 WP_210561721.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-104)

Antitoxin

Post-segregation antitoxin CcdA

(11-81)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11810.64 Da        Isoelectric Point: 4.5836

>T198971 WP_210561704.1 NZ_CP072844:999776-1000093 [Psychrosphaera aestuarii]
MPQFSLYKNKDKSTSRAYPFFVDVQSDLLNSLDTRIVIPLTSLELLEGSAPTHLCPIIHLEEGDFVILTQQTTSVPTKML
KEEVTDLRAFRNEIIGALDFLITGI

Download         Length: 318 bp

>T198971 NZ_CP097077:113022-113504 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACAAAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9223.34 Da        Isoelectric Point: 6.4611

>AT198971 WP_210561702.1 NZ_CP072844:999531-999776 [Psychrosphaera aestuarii]
MRNVHSTQPTKKATNLSLNSELLAEAKRLNINLSATMEKALEREVSAKLRDEWIQQNADAVESCNKLTEEHGLFSDSYRT
F

Download         Length: 246 bp

>AT198971 NZ_CP097077:112753-113031 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References