Detailed information of TA system TA198959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4918567..4919083
• Replicon: chromosome
• Accession: NZ_CP072826
• Organism: Klebsiella pneumoniae strain IRQBAS105c

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J9263_RS23970
• Protein ID: WP_117260273.1
• Coordinates: 4918799..4919083 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: J9263_RS23965
• Protein ID: WP_002886901.1
• Coordinates: 4918567..4918809 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9263_RS23950 (4914595)	4914595..4915335	+	741	WP_002886899.1	KDGP aldolase family protein	-
J9263_RS23955 (4915402)	4915402..4916556	+	1155	WP_002886900.1	lactonase family protein	-
J9263_RS23960 (4916579)	4916579..4918489	+	1911	WP_004152270.1	PRD domain-containing protein	-
J9263_RS23965 (4918567)	4918567..4918809	+	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
J9263_RS23970 (4918799)	4918799..4919083	+	285	WP_117260273.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J9263_RS23975 (4919087)	4919087..4919551	-	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
J9263_RS23980 (4919793)	4919793..4921931	-	2139	WP_040164650.1	anaerobic ribonucleoside-triphosphate reductase	-
J9263_RS23985 (4922288)	4922288..4923031	-	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
J9263_RS23990 (4923034)	4923034..4923207	-	174	WP_032410138.1	hypothetical protein	-
J9263_RS23995 (4923337)	4923337..4923600	+	264	WP_014908078.1	PTS sugar transporter subunit IIB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11127.96 Da
• Isoelectric Point: 10.3787

>T198959 WP_117260273.1 NZ_CP072826:4918799-4919083 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQVVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T198959 NZ_CP097076:326593-326961 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCTGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT198959 WP_002886901.1 NZ_CP072826:4918567-4918809 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT198959 NZ_CP097076:326375-326596 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0