Detailed information of TA system TA198957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4268322..4270003
• Replicon: chromosome
• Accession: NZ_CP072826
• Organism: Klebsiella pneumoniae strain IRQBAS105c

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: J9263_RS20755
• Protein ID: WP_015959269.1
• Coordinates: 4269128..4270003 (+)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: J9263_RS20750
• Protein ID: WP_130947194.1
• Coordinates: 4268322..4269080 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9263_RS20735 (4264172)	4264172..4264858	-	687	WP_004151733.1	tetratricopeptide repeat protein	-
J9263_RS20740 (4265088)	4265088..4267235	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
J9263_RS20745 (4267508)	4267508..4268236	+	729	WP_004177810.1	response regulator transcription factor	-
J9263_RS20750 (4268322)	4268322..4269080	+	759	WP_130947194.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
J9263_RS20755 (4269128)	4269128..4270003	+	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
J9263_RS20760 (4270128)	4270128..4271135	-	1008	WP_015959270.1	carbohydrate kinase family protein	-
J9263_RS20765 (4271210)	4271210..4272151	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
J9263_RS20770 (4272182)	4272182..4273180	-	999	WP_002885172.1	ribose ABC transporter permease	-
J9263_RS20775 (4273177)	4273177..4274697	-	1521	WP_049005954.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T198957 WP_015959269.1 NZ_CP072826:4269128-4270003 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T198957 NZ_CP097071:34906-35181 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAATT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCATGCACTAACAGGAAATTATA
TAGGTACACGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCCCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28532.93 Da
• Isoelectric Point: 10.0870

>AT198957 WP_130947194.1 NZ_CP072826:4268322-4269080 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQAVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT198957 NZ_CP097071:34647-34913 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Structures

Toxin

• AlphaFold DB: A6TH06