Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2357449..2358068 Replicon chromosome
Accession NZ_CP072826
Organism Klebsiella pneumoniae strain IRQBAS105c

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag J9263_RS11500 Protein ID WP_002892050.1
Coordinates 2357449..2357667 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag J9263_RS11505 Protein ID WP_002892066.1
Coordinates 2357694..2358068 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9263_RS11465 (2353496) 2353496..2353759 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
J9263_RS11470 (2353759) 2353759..2353899 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
J9263_RS11475 (2353896) 2353896..2354594 - 699 WP_117260135.1 GNAT family protein -
J9263_RS11480 (2354695) 2354695..2356146 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
J9263_RS11485 (2356121) 2356121..2356591 - 471 WP_002892026.1 YlaC family protein -
J9263_RS11490 (2356612) 2356612..2356752 + 141 WP_004147370.1 hypothetical protein -
J9263_RS11495 (2356724) 2356724..2357290 - 567 WP_002892030.1 maltose O-acetyltransferase -
J9263_RS11500 (2357449) 2357449..2357667 - 219 WP_002892050.1 HHA domain-containing protein Toxin
J9263_RS11505 (2357694) 2357694..2358068 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
J9263_RS11510 (2358554) 2358554..2361700 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
J9263_RS11515 (2361723) 2361723..2362916 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T198946 WP_002892050.1 NZ_CP072826:c2357667-2357449 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T198946 NZ_CP097066:2662584-2662727 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAACCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT198946 WP_002892066.1 NZ_CP072826:c2358068-2357694 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT198946 NZ_CP097066:c2662921-2662659 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References