Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1582980..1583570 Replicon chromosome
Accession NZ_CP072826
Organism Klebsiella pneumoniae strain IRQBAS105c

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag J9263_RS07865 Protein ID WP_023341911.1
Coordinates 1582980..1583312 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3S7DDD0
Locus tag J9263_RS07870 Protein ID WP_000288812.1
Coordinates 1583313..1583570 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9263_RS07840 (1579027) 1579027..1579272 + 246 WP_023284006.1 signal transduction protein PmrD -
J9263_RS07845 (1579402) 1579402..1580856 + 1455 WP_004148975.1 AMP nucleosidase -
J9263_RS07855 (1581222) 1581222..1582658 - 1437 WP_004151469.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
J9263_RS07865 (1582980) 1582980..1583312 - 333 WP_023341911.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J9263_RS07870 (1583313) 1583313..1583570 - 258 WP_000288812.1 antitoxin Antitoxin
J9263_RS07875 (1583905) 1583905..1584111 - 207 WP_117259919.1 helix-turn-helix transcriptional regulator -
J9263_RS07880 (1584108) 1584108..1584568 - 461 Protein_1560 hypothetical protein -
J9263_RS07885 (1584851) 1584851..1585399 - 549 WP_117259920.1 hypothetical protein -
J9263_RS07890 (1585478) 1585478..1587226 - 1749 WP_096106564.1 hypothetical protein -
J9263_RS25550 (1587577) 1587577..1587654 - 78 Protein_1563 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11927.87 Da        Isoelectric Point: 10.4722

>T198945 WP_023341911.1 NZ_CP072826:c1583312-1582980 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

>T198945 NZ_CP097066:2662584-2662727 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAACCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9442.92 Da        Isoelectric Point: 4.3566

>AT198945 WP_000288812.1 NZ_CP072826:c1583570-1583313 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT198945 NZ_CP097066:c2662473-2662327 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DDD0

References