Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1201813..1202470 Replicon chromosome
Accession NZ_CP072826
Organism Klebsiella pneumoniae strain IRQBAS105c

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag J9263_RS05855 Protein ID WP_002916310.1
Coordinates 1201813..1202223 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J9263_RS05860 Protein ID WP_002916312.1
Coordinates 1202204..1202470 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9263_RS05835 (1197813) 1197813..1199546 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
J9263_RS05840 (1199552) 1199552..1200265 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J9263_RS05845 (1200288) 1200288..1201184 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
J9263_RS05850 (1201285) 1201285..1201806 + 522 WP_002916308.1 flavodoxin FldB -
J9263_RS05855 (1201813) 1201813..1202223 - 411 WP_002916310.1 protein YgfX Toxin
J9263_RS05860 (1202204) 1202204..1202470 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J9263_RS05865 (1202716) 1202716..1203699 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
J9263_RS05870 (1203798) 1203798..1204457 - 660 WP_004174454.1 hemolysin III family protein -
J9263_RS05875 (1204621) 1204621..1204932 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
J9263_RS05880 (1204982) 1204982..1205710 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
J9263_RS05885 (1205829) 1205829..1207262 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T198944 WP_002916310.1 NZ_CP072826:c1202223-1201813 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T198944 NZ_CP097066:2662204-2662353 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTCAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGG
GTTTGGTATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT198944 WP_002916312.1 NZ_CP072826:c1202470-1202204 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT198944 NZ_CP097066:c2662487-2662286 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References