Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 1201813..1202470 | Replicon | chromosome |
Accession | NZ_CP072826 | ||
Organism | Klebsiella pneumoniae strain IRQBAS105c |
Toxin (Protein)
Gene name | cptA | Uniprot ID | W8UCT0 |
Locus tag | J9263_RS05855 | Protein ID | WP_002916310.1 |
Coordinates | 1201813..1202223 (-) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | W8UQ37 |
Locus tag | J9263_RS05860 | Protein ID | WP_002916312.1 |
Coordinates | 1202204..1202470 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J9263_RS05835 (1197813) | 1197813..1199546 | - | 1734 | WP_004149758.1 | single-stranded-DNA-specific exonuclease RecJ | - |
J9263_RS05840 (1199552) | 1199552..1200265 | - | 714 | WP_004174456.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
J9263_RS05845 (1200288) | 1200288..1201184 | - | 897 | WP_004144729.1 | site-specific tyrosine recombinase XerD | - |
J9263_RS05850 (1201285) | 1201285..1201806 | + | 522 | WP_002916308.1 | flavodoxin FldB | - |
J9263_RS05855 (1201813) | 1201813..1202223 | - | 411 | WP_002916310.1 | protein YgfX | Toxin |
J9263_RS05860 (1202204) | 1202204..1202470 | - | 267 | WP_002916312.1 | FAD assembly factor SdhE | Antitoxin |
J9263_RS05865 (1202716) | 1202716..1203699 | + | 984 | WP_023286864.1 | tRNA-modifying protein YgfZ | - |
J9263_RS05870 (1203798) | 1203798..1204457 | - | 660 | WP_004174454.1 | hemolysin III family protein | - |
J9263_RS05875 (1204621) | 1204621..1204932 | - | 312 | WP_004144734.1 | N(4)-acetylcytidine aminohydrolase | - |
J9263_RS05880 (1204982) | 1204982..1205710 | + | 729 | WP_002916321.1 | MurR/RpiR family transcriptional regulator | - |
J9263_RS05885 (1205829) | 1205829..1207262 | + | 1434 | WP_002916322.1 | 6-phospho-beta-glucosidase BglA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 16049.85 Da Isoelectric Point: 11.4778
>T198944 WP_002916310.1 NZ_CP072826:c1202223-1201813 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
Download Length: 411 bp
>T198944 NZ_CP097066:2662204-2662353 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTCAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGG
GTTTGGTATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA
ATGCGTATGCACGTATTTCCGAAATTCAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGG
GTTTGGTATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10480.98 Da Isoelectric Point: 5.1116
>AT198944 WP_002916312.1 NZ_CP072826:c1202470-1202204 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
Download Length: 267 bp
>AT198944 NZ_CP097066:c2662487-2662286 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GSW7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GY41 |