Detailed information of TA system TA198943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 50819..52407
• Replicon: chromosome
• Accession: NZ_CP072826
• Organism: Klebsiella pneumoniae strain IRQBAS105c

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: J2LTC9
• Locus tag: J9263_RS00245
• Protein ID: WP_004148372.1
• Coordinates: 50819..52141 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: J9263_RS00250
• Protein ID: WP_004176198.1
• Coordinates: 52141..52407 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9263_RS00230 (45875)	45875..48376	+	2502	WP_040025883.1	fimbria/pilus outer membrane usher protein	-
J9263_RS00235 (48364)	48364..49368	+	1005	WP_040025882.1	fimbrial protein	-
J9263_RS00240 (49510)	49510..50802	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
J9263_RS00245 (50819)	50819..52141	-	1323	WP_004148372.1	type II toxin-antitoxin system HipA family toxin	Toxin
J9263_RS00250 (52141)	52141..52407	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
J9263_RS00255 (52672)	52672..52998	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
J9263_RS00260 (52995)	52995..53495	-	501	WP_020804988.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
J9263_RS00265 (53473)	53473..54852	-	1380	WP_206552300.1	nucleobase:cation symporter-2 family protein	-
J9263_RS00270 (55198)	55198..56352	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
J9263_RS00275 (56333)	56333..57256	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49127.45 Da
• Isoelectric Point: 7.5357

>T198943 WP_004148372.1 NZ_CP072826:c52141-50819 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSLRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T198943 NZ_CP097066:c2656777-2656436 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
TTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGACAAGTAGTGATCTCACAA
CTGCAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT198943 WP_004176198.1 NZ_CP072826:c52407-52141 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT198943 NZ_CP097066:c2657007-2656777 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GCCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Structures

Toxin

• AlphaFold DB: J2LTC9