Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 5128171..5128693 Replicon chromosome
Accession NZ_CP072825
Organism Klebsiella pneumoniae strain IRQBAS103c

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag J9262_RS24925 Protein ID WP_210502169.1
Coordinates 5128171..5128455 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag J9262_RS24930 Protein ID WP_025368601.1
Coordinates 5128445..5128693 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9262_RS24905 (5123549) 5123549..5124675 + 1127 Protein_4901 conjugal transfer protein TraG N-terminal domain-containing protein -
J9262_RS24910 (5124741) 5124741..5125967 - 1227 WP_025368604.1 RNA-guided endonuclease TnpB family protein -
J9262_RS24915 (5126004) 5126004..5126429 + 426 WP_040120489.1 IS200/IS605 family transposase -
J9262_RS24920 (5126715) 5126715..5127941 - 1227 WP_042935575.1 RNA-guided endonuclease TnpB family protein -
J9262_RS24925 (5128171) 5128171..5128455 - 285 WP_210502169.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9262_RS24930 (5128445) 5128445..5128693 - 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J9262_RS24935 (5128984) 5128984..5130783 + 1800 WP_085803536.1 ATP-dependent helicase -
J9262_RS24940 (5131117) 5131117..5132112 + 996 WP_046654939.1 hypothetical protein -
J9262_RS24945 (5132257) 5132257..5132610 + 354 WP_004181774.1 hypothetical protein -
J9262_RS24950 (5132672) 5132672..5133493 + 822 WP_046664185.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10910.66 Da        Isoelectric Point: 10.6268

>T198940 WP_210502169.1 NZ_CP072825:c5128455-5128171 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVCSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T198940 NZ_CP097066:c2571133-2570990 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT198940 WP_025368601.1 NZ_CP072825:c5128693-5128445 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT198940 NZ_CP097066:2570871-2571057 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References