198939

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5010483..5011009 Replicon chromosome
Accession NZ_CP072825
Organism Klebsiella pneumoniae strain IRQBAS103c

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag J9262_RS24390 Protein ID WP_000323025.1
Coordinates 5010722..5011009 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag J9262_RS24385 Protein ID WP_000534858.1
Coordinates 5010483..5010722 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9262_RS24365 (5005755) 5005755..5006390 + 636 Protein_4790 transposase -
J9262_RS24370 (5006811) 5006811..5008049 + 1239 WP_003030308.1 IS110 family transposase -
J9262_RS24375 (5008525) 5008525..5009097 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
J9262_RS24380 (5009297) 5009297..5010220 + 924 WP_020277922.1 cation diffusion facilitator family transporter -
J9262_RS27580 (5010354) 5010354..5010458 - 105 Protein_4794 hypothetical protein -
J9262_RS24385 (5010483) 5010483..5010722 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
J9262_RS24390 (5010722) 5010722..5011009 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
J9262_RS24395 (5011081) 5011081..5011239 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
J9262_RS24400 (5011843) 5011843..5012817 + 975 WP_210502162.1 Hok/Gef family protein -
J9262_RS24405 (5013015) 5013015..5013392 - 378 WP_004181901.1 hypothetical protein -
J9262_RS24410 (5014081) 5014081..5015148 + 1068 WP_004181903.1 hypothetical protein -
J9262_RS24415 (5015304) 5015304..5015651 + 348 WP_004181904.1 hypothetical protein -
J9262_RS24420 (5015730) 5015730..5015963 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5009055..5101174 92119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T198939 WP_000323025.1 NZ_CP072825:5010722-5011009 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T198939 NZ_CP097066:c2496628-2496527 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT198939 WP_000534858.1 NZ_CP072825:5010483-5010722 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT198939 NZ_CP097066:2496402-2496582 [Enterococcus faecalis]
TGAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAG
TTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATAC
CGAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References