198937

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4754187..4754812 Replicon chromosome
Accession NZ_CP072825
Organism Klebsiella pneumoniae strain IRQBAS103c

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag J9262_RS23205 Protein ID WP_002882817.1
Coordinates 4754429..4754812 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag J9262_RS23200 Protein ID WP_004150355.1
Coordinates 4754187..4754429 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9262_RS23175 (4750178) 4750178..4750777 + 600 WP_004151865.1 glucose-1-phosphatase -
J9262_RS23180 (4750771) 4750771..4751631 + 861 WP_004146232.1 virulence factor BrkB family protein -
J9262_RS23185 (4751628) 4751628..4752065 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
J9262_RS23190 (4752110) 4752110..4753051 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
J9262_RS23195 (4753065) 4753065..4753982 - 918 WP_117260249.1 alpha/beta hydrolase -
J9262_RS23200 (4754187) 4754187..4754429 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
J9262_RS23205 (4754429) 4754429..4754812 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
J9262_RS23210 (4754986) 4754986..4755915 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
J9262_RS23215 (4755912) 4755912..4756547 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
J9262_RS23220 (4756544) 4756544..4757446 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T198937 WP_002882817.1 NZ_CP072825:4754429-4754812 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T198937 NZ_CP097066:486871-486987 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT198937 WP_004150355.1 NZ_CP072825:4754187-4754429 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT198937 NZ_CP097066:c487103-486898 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References